头花蓼不同入药部位总黄酮代谢模式研究进展  

Research Progression of Total Flavones Metabolic Model in the Different Medicinal Position of Polygonum capitatum Buch.-Ham.ex D.Don

作　　者：杨杰 尤伟方 付世青 陈晓庆 张瑜[2] YANG Jie;YOU Weifang;FU Shiqing(Bijie medical college,Bijie Guizhou551700,China)

机构地区：[1]毕节医学高等专科学校,贵州毕节551700 [2]重庆医药高等专科学校,重庆401331

出　　处：《四川中医》2023年第10期211-215,共5页Journal of Sichuan of Traditional Chinese Medicine

基　　金：贵州省基础研究计划资助项目(编号:黔科合基础-ZK[2023]一般003)

摘　　要：头花蓼皆为地上全草入药,富含黄酮类成分,治疗泌尿道感染疗效显著。但是头花蓼茎、花、叶等部位总黄酮含量差异悬殊,其基因组研究资源十分缺乏。课题组经过10余年对转录组、代谢组及其网络药理学的研究积累,有助于探索头花蓼不同入药部位总黄酮代谢模式。本文从头花蓼黄酮类成分药效研究、药效成分、基因表达等研究层次方面进行介绍,为头花蓼黄酮类成分最佳临床入药部位的选择提供理论依据。The medicinal position of Polygonum capitatum Buch.-Ham.e.x D.Don(PC)is whole herb on land.Of note,PC mainly contained many flavones treating urinary tract infection because of notable therapeutic effect.However,total flavones content in the stem,flower and leaf of PC existed in significant difference,and its genomics resource was very lacking.For ten years,topic accumulations in transcriptomes,metabolomics and network pharmacological research help to probe total flavones metabolic model in different medicinal position of PC.We should systematically introduce pharmacodynamics research,active ingredient and gene expression of PC,and provided theoretical basis for selecting the most medicinal position of flavones ingredient of PC.

关 键 词：头花蓼 入药部位 总黄酮 代谢模式 研究层次 

分 类 号：R284[医药卫生—中药学]