血清载脂蛋白A、膜联蛋白A2水平与稳定型心绞痛中医辨证分型的关系及意义  

Relationship and Significance of Serum Apolipoprotein A and Annexin A2 Levels and Traditional Chiense Medicine Syndrome Differentiation of Stable Angina Pectoris

作　　者：徐蕾蕾[1] 储晓慧 朱明明 唐海军[1] 李晓丽[1] 王丽晓[1] XU Leilei;CHU Xiaohui;ZHU Mingming(Department of Cardiology,Rugao Traditional Chinese Medicine Hospital,Nantong Jiangsu 226500,China)

机构地区：[1]如皋市中医院心病科,江苏如皋226500

出　　处：《四川中医》2023年第2期71-74,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:分析血清载脂蛋白A、膜联蛋白A2水平与稳定型心绞痛(UAP)中医辨证分型的关系及意义。方法:选取我院于2020年1月~2022年6月收治的230例UAP患者为研究对象,分析不同证型UAP患者血清载脂蛋白、膜联蛋白A2、血脂指标、C反应蛋白(CRP)、白细胞计数(WBC)、中性粒细胞百分比(NE%)、降钙素原(FIB)、国际标准比值(INR)的差异。结果:230例UAP患者以痰瘀互结证为主,共98例,占比42.61%;其次为气虚血瘀证63例,占比27.39%;第三和第四分别为气阴两虚证和气滞血瘀证,对应38例(16.62%)和31例(13.48%)。UAP患者中痰瘀互结证患者男性占比、BMI、载脂蛋白A、载脂蛋白B、膜联蛋白A2、TC、LDL-C、CRP高于其他3种证型,差异有统计学意义(P<0.05)。气阴两虚证患者TG低于其他3种证型,差异有统计学意义(P<0.05)。不同证型UAP患者HDL-C、WBC、NE%、FIB、INR比较,差异无统计学意义(P>0.05)。结论:UAP患者中男性占比、BMI、载脂蛋白A、载脂蛋白B、膜联蛋白A2、TC、LDL-C、CRP与痰瘀互结证有相关性,TG与气阴两虚证有相关性,临床有助于中医辨证分型的鉴别。Objective:To analyze the relationship and significance of serum apolipoprotein A and annexin A2 levels and TCM syndrome differentiation of stable angina pectoris(UAP).Methods:A total of 230 UAP patients admitted to our hospital from January 2020 to June 2022 were selected as the subjects,and the serum apolipoprotein,annexin A2,blood lipid indexes,C-reactive protein(CRP),and white blood cell count in patients with different syndromes of UAP were analyzed.(WBC),neutrophil percentage(NE%),procalcitonin(FIB),and international standard ratio(INR).Results:Among the 230 UAP patients,the syndrome of phlegm and blood stasis was the main one,accounting for 42.61%of the total,followed by 63 cases of Qi deficiency and blood stasis syndrome,accounting for 27.39%;the third and fourth were Qi and Yin deficiency and Qi syndrome Blood stasis syndrome,corresponding to 38 cases(16.62%)and 31 cases(13.48%).Among UAP patients,the proportion of males,BMI,apolipoprotein A,apolipoprotein B,annexin A2,TC,LDL-C,and CRP in patients with phlegm and blood stasis syndrome were higher than those in the other three syndrome types,and the difference was statistically significant(P<0.05).The TG of patients with Qi and Yin deficiency syndrome was lower than that of the other three syndrome types,and the difference was statistically significant(P<0.05).There was no significant difference in HDL-C,WBC,NE%,FIB and INR among patients with different syndromes of UAP(P>0.05).Conclusion:In UAP patients,the proportion of males,BMI,apolipoprotein A,apolipoprotein B,annexin A2,TC,LDL-C,and CRP are correlated with phlegm and blood stasis syndrome,and TG is correlated with Qi and Yin deficiency syndrome.It is clinically helpful for the identification of TCM syndrome differentiation.

关 键 词：稳定型心绞痛 中医辨证分型 血脂 载脂蛋白A 膜联蛋白A2 

分 类 号：R541.4[医药卫生—心血管疾病]