基于DID模型加味三仁汤对冠心病患者左心室重构的影响分析  

Influence Analysis of Modified Sanren Decoction on Left Ventricular Remodeling for Patients with Coronary Heart Disease Based on DID Model

作　　者：郭悦[1] 刘纯兴 于艳丽 GUO Yue;LIU Chunxing;YU Yanli(Department of Teaching Management,the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang Liaoning 110032,China;Department of Soft Injury,the Second Affiliated Hospital of Shenyang Medical College,Shenyang Liaoning 110000,China)

机构地区：[1]辽宁中医药大学附属医院教学管理部,辽宁沈阳110032 [2]沈阳医学院附属第二医院软伤科,辽宁沈阳110000

出　　处：《四川中医》2022年第8期74-78,共5页Journal of Sichuan of Traditional Chinese Medicine

基　　金：辽宁省自然科学基金项目(编号:201602501)

摘　　要：目的:探讨基于双重差分法(DID)模型加味三仁汤对冠心病患者左心室重构的影响。方法:前瞻性选取2019年2月至2020年6月在我院就诊的冠心病患者136例,按照随机数字表法分为对照组和观察组,各68例;对照组接受等西医标准化治疗;观察组在对照组基础上加服加味三仁汤;比较两组治疗前后中医证侯积分、治疗前后心功能、采用DID模型对比两组治疗前后不同时间点(治疗前、治疗后1周、1、6、12个月)左心室重构指标。结果:治疗后,观察组胸闷、胸痛、心悸气短、自汗中医证候积分均显著低于对照组(P<0.05);观察组LVEF较对照组高,6MWT较对照组远,LVEDV、LVESV、NT-proBNP水平较对照组低(P<0.05);观察组治疗后各时间点LVDd、LVDs水平较对照组低(P<0.05),DID回归模型显示,治疗后,冠心病患者LVDs下降407.4%(P<0.05),但治疗方式在时间上与总体治疗效应相反;冠心病患者LVDd对比差异无统计学意义(P>0.05),治疗1个月后,两组的治疗效应存在显著差异,且在治疗6个月后差异呈减小趋势。结论:加味三仁汤能够抑制冠心病患者左心室重构,改善临床症状,提高心功能水平。Objective:To explore the effect of Modified Sanren Decoction on left ventricular remodeling for patients with coronary heart disease based on the double difference method(DID)model.Methods:Prospectively selected 136 patients with coronary heart disease who were in our hospital from February 2019 to June 2020,and divided them into a controlled group and an observation group according to a random number table,with 68 cases in each.The controlled group received standard western medicine treatment;the observation group added Modified Sanren Decoction on the basis of the controlled group;the two groups were compared before and after treatment in TCM syndrome scores,heart function before and after treatment,and the DID model was used to compare the two groups at different time points before and after treatment(before treatment,1 week,1,6,12 months after treatment)left ventricular remodeling index.Results:After treatment,the scores of TCM syndromes of chest tightness,chest pain,palpitations,shortness of breath,and spontaneous sweating in the observation group were significantly lower than those in the controlled group(P<0.05).The LVEF of the observation group was higher than that of the controlled group,6 MWT was farther than that of the controlled group,and the levels of LVEDV,LVESV,and NT-proBNP were lower than those of the controlled group(P<0.05).The levels of LVDd and LVDs in the observation group were lower than those in the controlled group at each time point after treatment(P<0.05).The DID regression model showed that after treatment,the LVDs of patients with coronary heart disease decreased by 407.4%(P<0.05).The treatment effect was opposite;there was no statistically significant difference in the LVDd of patients with coronary heart disease(P>0.05).After 1 month of treatment,there was a significant difference in the treatment effect between the two groups,and the difference showed a decreasing trend after 6 months of treatment.Conclusion:Modified Sanren Decoction can inhibit left ventricular remodeling for pat

关 键 词：加味三仁汤 冠心病 左心室重构 双重差分法模型 

分 类 号：R259[医药卫生—中西医结合]