龙胆泻肝汤加减联合火针治疗女性迟发性痤疮疗效观察  

Clinical Curative Observation of Using Modified Longdan Xiegan Decoction Combined with Fire Needle in Treating Female Delayed Acne

作　　者：杨琳[1] 陈敏[1] 曹婷 YANG Lin;CHEN Min;CAO Ting(Department of Dermatology and Cosmetology,Neijiang Muhicpal Hospital of Traditional Chinese Medicine,Neijiang Sichuan 641000,China)

机构地区：[1]内江市中医医院皮肤美容科,四川内江641000

出　　处：《四川中医》2022年第7期143-146,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察龙胆泻肝汤加减联合火针治疗女性迟发性痤疮的临床疗效。方法:选取2018年4月~2020年4月内江市中医医院收治的女性迟发性痤疮患者100例,采用随机数字法分为对照组(n=50)和观察组(n=50)。对照组给予西药+火针治疗,观察组给予西药+火针+龙胆泻肝汤加减治疗。比较两组疗效、复发率和不良反应率,观察性激素水平和面部痤疮皮损评分的变化。结果:观察组痊愈11例,显效和有效分别21例和13例,总有效率为90.00%,高于对照组,差异有统计学意义(P<0.05)。治疗后,两组雌二醇(E2)、催乳素(PRL)较治疗前升高,睾酮(T)较治疗前降低,孕酮(P)和卵泡刺激素(FSH)与治疗前比较,差异无统计学意义(P>0.05)。与对照组比较,观察组治疗后的E2、PRL明显更高,T明显更低,P和FSH比较,差异无统计学意义(P>0.05)。治疗后,两组皮损类型、皮损数目、皮脂溢出、皮损颜色和肿胀破溃等评分较治疗前降低(P<0.05)。与对照组比较,观察组治疗后的面部痤疮皮损评分明显更低(P<0.05)。观察组在停药后3个月内复发率为12.00%,低于对照组的36.00%,两组不良反应比较,差异无统计学意义(P>0.05)。结论:龙胆泻肝汤加减联合火针治疗女性迟发性痤疮可有效减轻痤疮症状,调节性激素的分泌,提高疗效,降低复发率。Objective:To observe the clinical effect of using Longdan Xiegan Decoction combined with fire needling in the treatment of late-onset acne in women.Methods:A total of 100 female patients with late-onset acne who were admitted to Neijiang Municipal Hospital of Traditional Chinese Medicine from April 2018 to April 2020 were selected and divided into a controlled group(n=50)and an observation group(n=50)by the random number method.The controlled group was given western medicine+fire needle treatment,and the observation group was given western medicine+fire needle+Longdan Xiegan Decoction.The curative effect,recurrence rate and adverse reaction rate were compared between the two groups,and the changes in the level of sex hormones and facial acne lesions were observed.Results:In the observation group,11 cases were cured,21 cases were markedly effective and 13 cases were effective respectively.The total effective rate was 90.00%,which was higher than that of the controlled group.The difference was statistically significant(P<0.05).After treatment,estradiol(E)and prolactin(PRL)in the two groups were higher than before treatment,and testosterone(T)was lower than before treatment.Progesterone(P)and follicle stimulating hormone(FSH)were different from those before treatment.No statistical significance(P>0.05).Compared with the controlled group,the observation group had significantly higher Eand PRL after treatment,and significantly lower T.There was no statistically significant difference between P and FSH(P>0.05).After treatment,the scores of the two groups of skin lesion types,number of skin lesions,seborrhea,skin lesion color and swelling and ulceration were lower than those before treatment(P<0.05).Compared with the controlled group,the score of facial acne lesions in the observation group after treatment was significantly lower(P<0.05).The recurrence rate(12.00%)of the observation group within 3 months after stopping the drug was lower than that of the controlled group(36.00%).There was no difference in adverse reacti

关 键 词：龙胆泻肝汤 火针 女性迟发性痤疮 性激素 复发 

分 类 号：R275.9[医药卫生—中西医结合]