白头翁汤加味联合美辛唑酮栓治疗肛窦炎临床疗效及对患者炎性因子及复发的影响  

Effect of Modified Baitouweng Decoction Combined with Indometacin and Furazolidone Suppositories on Clinical Efficacy,Inflammatory Factors and Recurrence for Patients with Anal Sinusitis

作　　者：秦健 赵勇 洪敏 QIN Jian;ZHAO Yong;HONG Min(Department of Anorectal,Dazhou Central Hospital,Dazhou Sichuan 635000,China;Department of Neonatology,the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu Sichuan 610075,China)

机构地区：[1]达州市中心医院肛肠科,四川达州635000 [2]成都中医药大学附属医院新生儿科,四川成都610075

出　　处：《四川中医》2022年第4期86-89,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：四川省科技计划项目(编号:17YYJC1915)

摘　　要：目的:分析白头翁汤加味联合美辛唑酮栓治疗对肛窦炎患者临床疗效、炎性因子及复发的影响。方法:回顾性分析2018年6月~2019年6月本院收治的119例肛窦炎患者临床资料,根据治疗方式的差异分为研究组(n=61,白头翁汤加味联合美辛唑酮栓治疗)、对照组(n=58,美辛唑酮栓治疗)。对比两组临床疗效,治疗前后炎性因子、疼痛、证候积分及复发情况。结果:(1)研究组临床总有效率(96.72%)高于对照组临床总有效率(86.21%),差异具有统计学意义(P<0.05)。(2)两组患者治疗后的IL-10较治疗前升高,CRP、TNF-α水平较术前降低,研究组治疗后IL-10水平高于对照组,CRP、TNF-α水平低于对照组(P<0.05)。(3)两组治疗后VAS评分呈下降趋势,且于治疗7d后达到最低值,治疗后任一时间点研究组VAS评分均低于对照组(P<0.05)。(4)治疗后两组治疗前肛门不适、肛门潮湿程度积分均有所下降,且研究组下降程度较对照组显著(P<0.05)。(5)研究组复发率低于对照组(4.92%vs 18.97%),比较具有统计学意义(P<0.05)。(6)两组不良反应发生率比较无统计学意义(1.64%vs 1.72%)(P>0.05)。结论:白头翁汤加味联合美辛唑酮栓治疗疗效显著,可改善肛窦炎患者临床症状,减轻其炎症反应,降低复发率,安全性高,值得推广。Objective:To analyze the effect of Modified Baitouweng Decoction combined with Indometacin and Furazolidone Suppositories on clinical efficacy,inflammatory factors and recurrence of patients with anal sinusitis.Methods:The clinical data of 119 patients with anal sinusitis admitted to this hospital from June 2018 to June 2019 were retrospectively analyzed.According to the difference of treatment methods,they were divided into a study group(n=61,Modified Baitouweng Decoction combined with Indometacin and Furazolidone Suppositories)and a controlled group(n=58,Indometacin and Furazolidone Suppositories).The clinical efficacy,inflammatory factors,pain,syndrome scores and recurrence of the two groups were compared before and after treatment.Results:(1)The total clinical effective rate of the study group(96.72%)was higher than that of the controlled group(86.21%),and the difference was statistically significant(P<0.05).(2)In the two groups,the IL-10 levels of patients after treatment were higher than those before treatment,and the levels of CRP and TNF-αwere lower than those before operation.After treatment,the IL-10 level of the study group was higher than that of the controlled group,and the levels of CRP and TNF-αwere lower than those of the controlled group(P<0.05).(3)The VAS scores of the two groups showed a downward trend after treatment,and reached the lowest value 7 days after treatment.The VAS score of the study group was lower than that of the controlled group at any point after treatment(P<0.05).(4)After treatment,the scores in anal discomfort and anal dampness in the two groups decreased,and the decrease in the study group was more significant than that in the controlled group(P<0.05).(5)The recurrence rate of the study group was lower than that of the controlled group(4.92%vs 18.97%),and the difference was statistically significant(P<0.05).(6)There was no significant difference in the incidence of adverse reactions between the two groups(1.64%vs 1.72%)(P>0.05).Conclusion:Modified Baitouweng Decoction comb

关 键 词：白头翁汤加味 美辛唑酮栓 肛窦炎 临床疗效 炎性因子 复发 

分 类 号：R657.13[医药卫生—外科学]