定痛救心汤加味治疗气阴两虚证冠心病的疗效及心电图、自主神经功能变化观察  

Efficacy of Modified Dingtong Jiuxin Decoction on Coronary Heart Disease of Qi-Yin Deficiency Syndrome and the Changes of Electrocardiogram and Autonomic Nervous Function

作　　者：冯国榜 梁振炼 符方旭 FENG Guobang;LIANG Zhenlian;FU Fangxu(Department of Emergency,the People's Hospital of Wenchang City,Wenchang Hai'nan 571300,China;Department of General medicine,The People's Hospital of Wenchang City,Wenchang Hai'nan 571300,China)

机构地区：[1]文昌市人民医院急诊科,海南文昌571300 [2]文昌市人民医院全科医学科,海南文昌571300

出　　处：《四川中医》2022年第3期81-84,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探究定痛救心汤加味治疗气阴两虚证冠心病的疗效及心电图、自主神经功能变化观察。方法:选择2019年7月~2020年7月在我院心内科就诊的105例气阴两虚证冠心病患者,用随机数字表法分为观察组(n=52)和对照组(n=53),对照组采用单纯的西药治疗,观察组在对照组的基础上加用定痛救心汤加味治疗,治疗6周后,对比2组患者的临床疗效、心电图疗效、中医症候评分、自主神经功能。结果:两组临床疗效对比:观察组临床总有效率为92.30%,对照组为73.59%,观察组临床疗效优于对照组,差异具有统计学意义(P<0.05);两组中医症状积分比较,观察组各项中医证候评分低于对照组(P<0.05);两组心电图疗效对比:观察组心电图总有效率为86.53%,对照组为67.92%,观察组心电图疗效优于对照组,差异具有统计学意义(P<0.05);两组神经自主功能调节情况对比:治疗后中心率变异性(HRV)参数中观察组期间标准差(SDNN)、均值标准差(SDANN)、差值均方的平方差(RMSSD)、高频成分(HF)高于对照组(P<0.05),观察组低频成分(LF)/高频成分(HF)比值小于对照组(P<0.05)。结论:定痛救心汤加味治疗气阴两虚证冠心病,能提高患者临床疗效和心电图疗效,降低中医症状评分,调节自主神经功能。Objective:To explore the efficacy of using Modified Dingtong Jiuxin Decoction in the treatment of coronary heart disease of Qi-Yin deficiency syndrome,and to observe the changes of electrocardiogram and autonomic nervous function.Methods:A total of 105 patients with coronary heart disease of Qi-Yin deficiency syndrome who were treated in the department of cardiology of the hospital were selected between July 2019 and July 2020,and they were divided into an observation group(n=52)and a controlled group(n=53)by using the random number table method.The controlled group was treated with western medicine alone,and the observation group was additionally treated with Modified Dingtong Jiuxin Decoction on the basis of the controlled group.After 6 weeks of treatment,the clinical efficacy,electrocardiogram efficacy,scores of TCM syndromes and autonomic nervous function of the two groups were compared.Results:The clinical efficacy was 92.30%in the observation group and was 73.59%in the controlled group,and the effective rate of the observation group was higher than that of the controlled group(P<0.05).The scores of various syndromes in the observation group were lower than those in the controlled group(P<0.05).As for electrocardiogram efficacy in the two groups,the effective rate of electrocardiogram was 86.53%in the observation group and was 67.93%in the controlled group,and the effective rate of the observation group was higher than that of the controlled group(P<0.05).Comparison of neuroautonomous function adjustment in the two groups showed that the heart rate variability(HRV)parameters such as standard deviation of of NN intervals(SDNN),standard deviation of average NN intervals(SDANN),root mean square of successive difference(RMSSD)and high-frequency component(HF)after treatment were higher in the observation group than those in the controlled group(P<0.05),while the ratio of low-frequency component(LF)/high-frequency component(HF)in the observation group was lower than that in the controlled group(P<0.05).Conclusion:

关 键 词：定痛救心汤 气阴两虚证冠心病 心电图 自主神经功能 

分 类 号：R259[医药卫生—中西医结合]