化瘀消癍汤联合盐酸贝那普利片治疗儿童紫癜性肾炎疗效及对中医症候积分、肾功能和免疫功能的影响  

Efficacy of Using Huayu Xiaoban Decoction Combined with Benazepril Hydrochloride Tablets in the Treatment of Children with Henoch-Schonlein Purpura Nephritis and Its Influence on Traditional Chinese Medicine Syndromes Scores,Renal Function and Immune Function

作　　者：徐燕莉[1] XU Yanli(Department of Nephrology,Luzhou Hospital of Traditional Chinese Medicine,Luzhou Sichuan 646000,China)

机构地区：[1]泸州市中医医院肾病科,四川泸州646000

出　　处：《四川中医》2022年第1期120-124,共5页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察化瘀消癍汤联合盐酸贝那普利片治疗儿童紫癜性肾炎疗效及对中医症候积分、肾功能和免疫功能的影响。方法:随机选取我院97例儿童紫癜性肾炎患者为研究对象,按照随机数值表法分为观察组和对照组,对照组(n=48)给予盐酸贝那普利片治疗,观察组(n=49)在对照组基础上加以化瘀消癍汤治疗,观察治疗后两组疗效、中医症候积分、肾功能(血肌酐、尿素水平、肾小球滤过率、24h尿蛋白定量)、免疫功能(CD_(3)^(+)、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+))、血清炎性因子[白介素1β(IL-1β)、白介素-17(IL-17)、单核细胞趋化蛋白(MCP-1)、肿瘤坏死因子(TNF-α)]水平变化及不良反应。结果:治疗2个月后,观察组临床有效率为95.91%,对照组为81.25%,两组对比差异有统计学意义(P<0.05);两组中医证候积分均显著降低(P<0.05),且治疗后组间对比差异显著(P<0.05);治疗2个月后,两组血肌酐、尿素水平、24h尿蛋白定量均显著降低(P<0.05),肾小球滤过率均显著升高(P<0.05),且治疗后组间对比差异显著(P<0.05);两组CD_(3)^(+)、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)水平均显著升高(P<0.05),CD_(8)^(+)水平均显著降低(P<0.05),且治疗后组间对比差异显著(P<0.05);两组IL-1β、IL-17、MCP-1、TNF-α水平均显著降低(P<0.05),且治疗后组间对比差异显著(P<0.05);治疗期间,观察组不良反应率为4.08%;对照组为8.33%,两组对比差异无统计学意义(P>0.05)。结论:化瘀消癍汤联合盐酸贝那普利片治疗儿童紫癜性肾炎可提高治疗效果,改善临床证候,增强肾功能和免疫功能,降低不良反应,相对安全。Objective:To explore the efficacy of using Huayu Xiaoban Decoction combined with Benazepril Hydrochloride Tablets in the treatment of children with Henoch-Schonlein purpura nephritis and its influence on TCM syndromes scores,renal function and immune function.Methods:Ninety-seven children with Henoch-Schonlein purpura nephritis in our hospital were randomly selected as the research subjects,and they were divided into an observation group and a controlled group according to the random number table method.The controlled group(n=48)was treated with Benazepril Hydrochloride Tablets,and the observation group(n=49)was additionally given Huayu Xiaoban Decoction on the basis of the controlled group.After treatment,the efficacy,TCM symptoms scores,renal function(serum creatinine,urea level,glomerular filtration rate,24h urine protein quantification),immune function(CD_(3)^(+),CD_(4)^(+),CD_(4)^(+)/CD_(8)^(+)),serum inflammatory factors[interleukin 1β(IL-1β),interleukin-17(IL-17),monocyte chemoattractant protein(MCP-1),tumor necrosis factor(TNF-α)]and adverse reactions were observed in the two groups.Results:After 2months of treatment,the clinical effective rate was 95.91%in the observation group and 81.25%in the controlled group(P<0.05).The scores of TCM syndromes in the two groups were significantly reduced(P<0.05),and the scores between the groups were significantly different after treatment(P<0.05).After 2months of treatment,the serum creatinine,urea level and 24h urine protein quantification were decreased significantly in the two groups(P<0.05)while the glomerular filtration rate was significantly increased(P<0.05),and there were significant differences between the groups after treatment(P<0.05).The levels of CD_(3)^(+),CD_(4)^(+)and CD_(4)^(+)/CD_(8)^(+)in the two groups were significantly increased(P<0.05)while the CD_(8)^(+)level was significantly reduced(P<0.05),and the differences between the groups after treatment were significant(P<0.05).The levels of IL-1β,IL-17,MCP-1 and TNF-α in the two groups were sig

关 键 词：儿童紫癜性肾炎 肾功能 免疫功能 血清炎性因子 

分 类 号：R726.9[医药卫生—儿科]