类风湿关节炎患者血清IL-6、IL-17表达及其意义分析  

Analysis of serum IL-6 and IL-17 expression and their significance in patients with rheumatoid arthritis

作　　者：冷俊 林豪 周晔 LENG Jun;LIN Hao;ZHOU Ye(Department of Clinical Laboratory,Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences,Shanghai 202150,China)

机构地区：[1]上海健康医学院附属崇明医院检验科,上海202150

出　　处：《生命科学仪器》2023年第6期139-142,共4页Life Science Instruments

摘　　要：目的:通过开展回顾性分析,观察血清白细胞介素-6(IL-6)、白细胞介素-17(IL-17)在类风湿关节炎(RA)患者中的表达及其意义,为RA早期诊疗提供新思路。方法:回顾性分析,采集我院2019年7月至2022年7月收治的110例RA患者基线资料,依据DAS28评分系统评估RA患者病情活动度并分为稳定组(DAS28评分≤3.2分)与进展组(DAS28评分>3.2分),观察两组患者血清IL-6、IL-17表达情况,并分析上述血清表达与疾病活动度的关系。结果:入组110例RA患者经DAS28评分系统评估显示,高度活动37例,平均得分(7.21±1.52)分,中度活动度32例,平均得分(4.12±0.67)分,低度活动度41例,平均得分(2.15±0.52)分;与稳定组相比,进展组血清IL-6、IL-17表达均较高,DAS28平均得分较稳定组高(P<0.05),组间其他资料对比(P>0.05);建立Logistic回归模型,结果显示,血清IL-6、IL-17表达与RA患者疾病活动度有关,且血清IL-6(OR=1.176,95%CI:1.028~1.346)、IL-17(OR=1.117,95%CI:1.044~1.196)过表达是导致RA患者疾病进展的危险因素(P<0.05);绘制ROC曲线显示,血清IL-6、IL-17表达单独及联合预测RA患者疾病活动度的AUC均>0.80,预测价值较理想。结论:血清IL-6、IL-17表达与RA患者疾病活动度密切相关,血清IL-6、IL-17过表达是导致RA患者疾病进展的重要因素。Objective:To observe the expression of serum interleukin-6(IL-6)and interleukin-17(IL-17)in patients with rheumatoid arthritis(RA)and their significance by conducting a retrospective analysis.Methods:Retrospective analysis was performed to collect baseline data from 110 RA patients admitted to our hospital from February 2020 to February 2023,and to assess the disease activity of RA patients according to the DAS28 scoring system and divide them into stable group(DAS28 score≤3.2)and progressive group(DAS28 score>3.2),and to observe the expression of serum IL-6 and IL-17 in both groups and analyze The relationship between the above serum expression and disease activity was analyzed.Results:The results of 110 RA patients enrolled in the group were evaluated by the DAS28 scoring system,which showed that 37 patients were highly active with a mean score of(7.21±1.52),32 patients were moderately active with a mean score of(4.12±0.67),and 41 patients were hypoactive with a mean score of(2.15±0.52);compared with the stable group,serum IL-6 and IL-17 expressions were higher in the progressive group,and the mean DAS28 score was higher in the progressive group.Compared with the stable group,the mean score of DAS28 was higher than that of the stable group(P<0.05),and other information was compared between groups(P>0.05);logistic regression models were established,and the results showed that serum IL-6 and IL-17 expression were related to disease activity in RA patients,and serum IL-6 and IL-17 overexpression was a risk factor for disease progression in RA patients(OR>1,P<0.05);plotting ROC curves showed that the AUC of serum IL-6 and IL-17 expression alone and in combination to predict disease activity in RA patients was>0.80,which was a good predictive value.Conclusion:Serum IL-6 and IL-17 expression are closely related to disease activity in RA patients,and serum IL-6 and IL-17 overexpression is an important factor leading to disease progression in RA patients.

关 键 词：类风湿关节炎 白细胞介素-6 白细胞介素-17 疾病活动度 相关性 

分 类 号：R684.3[医药卫生—骨科学]