小胶质细胞在太空飞行导致的认知障碍中的作用  

The role of microglia in spaceflight-induced cognitive impairment

作　　者：孙精言 陈姿喧[1] 邓玉林[1] SUN Jingyan;CHEN Zixuan;DENG Yulin(Beijing institute of technology,Beijing,100081)

机构地区：[1]北京理工大学,北京100081

出　　处：《生命科学仪器》2023年第4期9-17,共9页Life Science Instruments

摘　　要：长期太空飞行过程中的微重力和电离辐射是诱发宇航员认知功能下降的主要原因。小胶质细胞作为脊椎动物中枢神经系统中的常驻免疫细胞,对大脑维持正常生理功能尤为重要。但目前尚未发现有关小胶质细胞在长期太空飞行过程中导致的认知障碍中的作用的讨论。因此,本综述首先讨论了微重力与电离辐射引起的认知障碍,随后从小胶质细胞在认知功能障碍中的作用出发,探讨了其在长期太空飞行过程中可能发挥的作用,以及将来可能的治疗或预防认知功能障碍的手段。Microgravity and ionizing radiation during long-term space flight are the main reasons for the decline of astronauts'cognitive function.As resident immune cells in the central nervous system of vertebrates,microglia are particularly important for the brain to maintain normal physiological function.However,there is no discussion about the role of microglia in cognitive impairment caused by long-term space flight.Therefore,this review first discusses the cognitive impairment caused by microgravity and ionizing radiation,and then discusses the possible role of microglia in long-term space flight from the role of microglia in cognitive dysfunction.and possible ways to treat or prevent cognitive impairment in the future.

关 键 词：小胶质细胞 神经元 认知障碍 太空飞行 

分 类 号：Q2-06[生物学—细胞生物学]