原发性醛固酮增多症和原发性高血压患者生化指标的对比分析  

Comparative analysis of biochemical indexes between primary aldosteronism and essential hypertension

作　　者：杨二丽 范婷婷[2] 丁旵东[1] Yang Erli;Fan Tingting;Ding Chandong(Department of Geriatric Cardiovascular Medicine,The Second Affiliated Hospital of Anhui Medical university,Hefei,Anhui 230601,China;Department of Cardiovascular Medicine,The Second Affiliated Hospital of Anhui Medical university,Hefei,Anhui 230601,China)

机构地区：[1]安徽医科大学第二附属医院老年心血管内科,安徽合肥230601 [2]安徽医科大学第二附属医院心血管内科,安徽合肥230601

出　　处：《生命科学仪器》2023年第3期148-151,共4页Life Science Instruments

基　　金：安徽省仿生感知与先进机器人技术重点实验室开放基金项目(LBSART202007)

摘　　要：目的:探讨原发性高血压(essential hypertension,EHT)和原发性醛固酮增多症(primary aldosteronism,PA)以及不同分型PA患者的生化指标差异。方法:连续纳入2009年9月至2022年9月在安徽医科大学第二附属医院住院治疗的131例PA患者,根据肾上腺CT的结果,分为腺瘤组(90例)、非腺瘤组(41例)。127例EHT患者作为对照组,比较组间血糖(plasma glucose,PG)、总胆固醇(total cholesterol,TC)、甘油三酯(triglycerides,TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL)、低密度脂蛋白胆固醇(low density lipoprotein cholesterin,LDL)等的差异。结果:EHT(107/21)与腺瘤(43/47)、EHT与非腺瘤(21/20)组间的性别构成比有显著差异。EHT与腺瘤、EHT与非腺瘤在年龄、体重指数(body mass index,BMI)上均存在显著性差异(P<0.05)。EHT与腺瘤、腺瘤与非腺瘤组间的TG均有显著差异(P<0.05)。TC与LDL在EHT与腺瘤组间有统计学差异(P<0.05)。结论:相比PA,EHT的脂代谢指标异常更明显。非腺瘤组PA患者甘油三酯(TG)显著升高,其余生化指标相比腺瘤组也有不同程度升高,但差异无统计学意义。Objective;To investigate the biochemical and hormonal differences of patients with essential hypertension(EHT).primary aldosteronism(PA)and between different types of PA.Methods;A total of 131 PA patients hospitalized in the Second Affiliated Hospital of Anhui Medical University from September 2009 to September 2022 were included.According to the results of adrenal CT.the PA patients were divided into adenoma group(90 cases)and non-adenoma group(41 cases).127 patients with EHT as control group.The differences of blood glucose(PG).total cholesterol(TC).triglyceride(TG).high density lipoprotein cholesterol(HDL)low density lipoprotein cholesterol(LDL).Results:There were significant differences in sex composition ratio between EHT(107/21)and adenoma group(43/47).between EHT and non-adenoma group(21/20).Age.body mass index(BMI)between EHT and adenoma group.EHT and non-adenoma group were significantly different(P<0.05).There were significant differences in TG between EHT and adenoma group,adenoma and non-adenoma group.There were statistical differences in TC and LDL between EHT and adenoma groups(P<0.05).Conclusions:Compared with non-adenoma group.TG of PA patients in the non-adenoma group was significantly increased.Other biochemical indexes were also increased to varying degrees compared with the adenoma group,but the difference was not statistically significant.

关 键 词：原发性醛固酮增多症 原发性高血压 腺瘤 非腺瘤 生化指标 

分 类 号：R544.1[医药卫生—心血管疾病]