妇科疾病合并糖尿病患者手术治疗前后 HbAlc与RBP4水平的变化及其意义  

Changes and significance of HbAlc and RBP4 levels in patients with gynecological diseases and diabetes mellitus before and after surgical treatment

作　　者：李丽[1] 高伟聪[2] 刘素巧[1] 张中华 朱向辉[2] LI li;GAO Weicong;LIU Suqiao;ZHANG Zhonghua;ZHU Xianghui(Gynecology&Obstetrics,Shijiazhuang City Second Hospital,China,050000;clinical laboratory,Shijiazhuang City Second Hospital,China,050000)

机构地区：[1]石家庄市第二医院妇产科,河北石家庄050000 [2]石家庄市第二医院检验科,河北石家庄050000

出　　处：《生命科学仪器》2023年第3期120-123,共4页Life Science Instruments

基　　金：石家庄市科学技术研究与发展指导计划项目(171461463)

摘　　要：目的:探究妇科疾病合并糖尿病患者手术治疗前后糖化血红蛋白(HbAlc)与视黄醇结合蛋白4(RBP4)水平的变化及其意义。方法:选取2017年2月-2020年12月在本院进行手术治疗的妇科疾病合并糖尿病患者112例作为观察组;同时选取同期在我院治疗的无糖尿病的妇科疾病患者108例作为对照组。用高效液相色谱法测定患者HbA1c水平;用ELISA法测定血清中RBP4水平;Logistic回归分析影响患者预后的危险因素;ROC曲线分析HbAlc、RBP4水平对患者预后的预测价值。结果:术前,观察组HbAlc、RBP4水平高于对照组;术后,两组患者HbAlc、RBP4水平均较术前有所下降,观察组各因子水平仍显著高于对照组(P<0.05)。糖尿病病程、HbAlc、RBP4是影响患者预后不良的危险因素(P<0.05)。HbAlc和RBP4预测妇科疾病合并糖尿病患者预后的曲线下面积(AUC)分别为0.746和0.785,敏感度为69.60%和73.90%,特异性为75.30%和79.80%。结论:妇科疾病合并糖尿病患者经手术治疗后,HbAlc与RBP4水平均有所下降,测定二者水平能有效反映患者预后情况。Objective:To explore the changes and significance of the levels of glycosylated hemoglobin(HbAlc)and retinol-binding protein 4(RBP4)in patients with gynecological diseases and diabetes mellitus before and after surgical treatment.Methods:A total of 112 patients with gynecological diseases and diabetes who underwent surgical treatment in our hospital from February 2017 to December 2020 were gathered as the observation group;at the same time.108 patients with gynecological diseases without diabetes who underwent surgery in our hospital were collected as the control group.HbAlc level was determined by high performance liquid chromatography;the levels of RBP4 in were determined by ELISA;the risk factors affecting the prognosis of patients were analyzed by Logistic regression;the predictive value of HbAlc and RBP4 levels on the prognosis of patients was analyzed by ROC curve.Results;Before surgery,the levels of HbAlc and RBP4 in the observation group were higher than those in the control group;after surgery,the levels of HbAlc and RBP4 in the two groups were decreased compared with those before surgery,and the levels in the observation group were still higher than those in the control group(P<0.05).The duration of diabetes.HbAlc and RBP4 level were risk factors for poor prognosis(P<0.05).The area under the curve(AUG)of HbAlc and RBP4 for predicting prognosis in patients with gynecological diseases and diabetes was 0.746 and 0.785.with a sensitivity of 69.60%and 73.90%and a specificity of 75.30%and 79.80%.respectively.Conclusion;After surgical treatment of gynecological diseases combined with diabetes mellitus.the levels of HbAlc and RBP4 decreased,and the determination of the two levels can effectively reflect the prognosis of patients.

关 键 词：妇科疾病 糖尿病 糖化血红蛋白 视黄醇结合蛋白4 

分 类 号：R271.1[医药卫生—中医妇科学]