纳米药物在体动力学转运特性研究设备综述  

A review of equipment for the study of in vivo kinetic transport properties of nano-drugs

作　　者：李怡燃 周慧晶 陈超凡 王飞龙 黄海鹏 钱志余[1] 李韪韬[1] LI Yiran;ZHOU Huijing;CHEN Chaofan;QIAN Zhiyu;LI Weitao(Department of Biomedical Engineering,Nanjing University of Aeronautics and Astronautics,Nanjing,210016)

机构地区：[1]南京航空航天大学,生物医学工程系,南京210016

出　　处：《生命科学仪器》2022年第5期12-18,共7页Life Science Instruments

基　　金：国家自然科学基金面上项目(61875085);自然科学基金国家重大科研仪器研制项目(81727804)

摘　　要：本文介绍了纳米药物药代动力学的研究现状及在体动力学转运特性的概念,并重点讨论了纳米药物在活体动物靶细胞内的动态监测设备的实现方法及其进展,包括纳米药物药代动力学的研究以及通过采用光学显微镜成像技术、激光共聚焦显微成像技术、双光子显微成像技术等对药物在体内转运特性的监测,并从技术原理、技术特征等方面阐述了纳米药物在体内的动力学转运特性以及监测药物转运过程的研究设备现状和不足,突出了纳米药物在体动力学转运特性研究的重要性。This paper introduces the research status of nanomedicine pharmacokinetics and the concept of in vivo kinetic transport properties,and focuses on the realization method and progress of the dynamic monitoring equipment of nanomedicines in target cells of living animals,including the research of pharmacokinetics of nano drugs,and the monitoring of drug transport characteristics in vivo by using optical microscope imaging technology,laser confocal microscopy imaging technology,two-photon microscopy imaging technology,etc,from the technical principles and technical characteristics,the in vivo kinetic transport characteristics of nanodrugs and the research status and deficiencies of monitoring the drug transport process were expounded,highlighting the importance of nano-drugs in vivo kinetic transport characteristics research.

关 键 词：纳米药物 药代动力学 在体 转运特性 激光共聚焦显微成像 

分 类 号：O59[理学—应用物理]