基于微纳传感调控技术的细胞胞内电子学的研究进展  

Research Advance in Intracellular Electronics Based on Micronano Sensing and Regulation Technology

作　　者：徐冬馨 方佳如 胡宁 XU Dongxin;FANG Jiaru;HU Ning(School of Electronics and Information Technology,Sun Yat-sen University,Guangzhou 510006;ZJU-Hangzhou Global Scientific and Technological Innovation Center,Department of Chemistry,Zhejiang University,Hangzhou 310058)

机构地区：[1]中山大学,电子与信息工程学院,广州510006 [2]浙江大学,杭州国际科创中心,化学系,杭州310058

出　　处：《生命科学仪器》2022年第4期4-12,共9页Life Science Instruments

基　　金：国家自然科学基金资助(项目号:62171483,82061148011)

摘　　要：建立可靠的电生理记录平台对于心脏病学和神经科学的研究至关重要。近十年来,基于微纳传感调控技术的器件被开发用于电生理平台的搭建,其独特的形貌优势和新颖的加工方式,使得高通量、高保真的电信号记录有望被实现。本综述分别从微纳传感调控器件的材料、结构、加工和穿膜策略等方面进行了总结,并对其在心肌细胞和神经细胞电生理检测上的应用进行了分析。在微纳传感调控技术所面临的机遇挑战下,对其广阔的发展前景进行了展望,希望借助其快速发展来推动更高层次的电生理平台搭建,以满足实验研究以及临床应用的需求。The development of a reliable electrophysiological recording platform is essential for cardiology and neuroscience research.In the last decade,micro-nano electronics are integrated into electrophysiological platforms with the unique morphological advantages and novel fabrication approaches,which are expected to achieve highthroughput and high-fidelity signal recording.In this review,we summarize micro-nano electronics in terms of materials,geometry,fabrication,and membrane penetration strategies,respectively,and analyze the application of micro-nano electronics to electrophysiological detection of cardiomyocytes and neurons.With an outlook on the opportunities,challenges,and broad prospects of micro-nano electronics,we expect to promote the development of intracellular electrophysiological platforms to meet the needs of experimental research and clinical applications.

关 键 词：微纳传感调控技术 细胞内电生理 电兴奋细胞 纳米生物界面 

分 类 号：TP212.3[自动化与计算机技术—检测技术与自动化装置]