钙网蛋白在寄生虫感染与免疫中的研究进展  

Research progress on the role of calreticulin in parasite infection and immunity

作　　者：张晶[1,2] 田晓薇 杨振科 梅雪芳 张振超 李祥瑞 王帅 ZHANG Jing;TIAN Xiaowei;YANG Zhenke;MEI Xuefang;ZHANG Zhenchao;LI Xiangrui;WANG Shuai(Department of Pathogenic Biology,School of Basic Medical Scineces,Xinxiang Medical University,Xinxiang,Henan 453003,China;Xinxiang Key Laboratory of Pathogenic Biology,Xinxiang,Henan 453003,China;College of Veterinary Medicine,Nanjing Agricultural University,Nanjing,Jiangsu 210095,China)

机构地区：[1]新乡医学院基础医学院,河南新乡453003 [2]新乡市病原生物学重点实验室,河南新乡453003 [3]南京农业大学动物医学院,江苏南京210095

出　　处：《热带医学杂志》2023年第10期1481-1486,共6页Journal of Tropical Medicine

基　　金：河南省科技攻关计划项目(232102311142);河南省高等学校重点科研项目(22A310004)

摘　　要：钙网蛋白(CRT)是一种主要存在于细胞内质网中高度保守的钙结合蛋白,由N、P和C结构功能区组成,在生物体内分布广泛。寄生虫CRT由虫体分泌或在虫体表面表达,在虫体感染与免疫过程中发挥重要作用。寄生虫感染宿主后,CRT作为一种抗原成分被宿主免疫系统识别,通过促进细胞成熟增殖分化,分泌细胞因子等方式提供免疫保护;将重组CRT作为疫苗免疫小鼠,在攻毒的小鼠模型中提供免疫保护。同时,寄生虫CRT通过干扰宿主补体激活的初始阶段或作为毒力因子参与寄生的建立及维持。不仅如此,CRT还可通过免疫佐剂、抑制血管生长与受体结合等方式发挥抑癌作用。本文将围绕上述内容展开综述,以期为探索寄生虫感染防治新途径提供新思路。Calreticulin(CRT)is a highly conserved calcium-binding protein which mainly exists in the endoplasmic reticulum.It is composed of the structural and functional domain of N,P and C and is widely distributed in organisms.Parasite CRT is secreted or expressed on the surface of parasite,which plays an important role in the process of infection and immunity.After parasites infect the host,CRT is recognized by the host immune system as an antigen component,which provides immune protection by promoting cell maturation,proliferation and secreting cytokines.Recombinant CRT is used as a vaccine to immunize mice to provide immune protection in the challenged mouse model.At the same time,parasite CRT participates in the establishment and maintenance of parasitism by interfering with the initial stage of host complement activation or as a virulence factor.Moreover,CRT can also inhibit cancer by means of immune adjuvants,inhibiting angiogenesis and binding to receptors.This article will review the above contents in order to provide new ideas for exploring new ways of prevention and treatment of parasite infection.

关 键 词：寄生虫 钙网蛋白 免疫 补体 毒力因子 抗肿瘤 

分 类 号：R38[医药卫生—医学寄生虫学]