广州市2019年健康人群百日咳抗体水平调查  

Survey of pertussis antibody levels in healthy people in Guangzhou in 2019

作　　者：王安娜[1] 贺晴[1] 陶霞[1] 马钰[1] 和鹏[1] 吴新伟[1] WANG An⁃na;HE Qing;TAO Xia;MA Yu;HE Peng;WU Xin⁃wei(Guangzhou Center for Disease Control and Prevention,Guangzhou,Guangdong 510440,China)

机构地区：[1]广州市疾病预防控制中心,广东广州510440

出　　处：《热带医学杂志》2022年第12期1734-1737,共4页Journal of Tropical Medicine

基　　金：广州市卫生健康科技一般引导项目(20211A011058);广州市重点实验室基础研究计划项目(202102100001);广州市医学重点学科(2021-2023-11)

摘　　要：目的调查广州市2019年健康人群百日咳抗体水平及人群百日咳潜在感染情况。方法采用单纯随机抽样法选取广州市全部11个区全年龄段健康人群收集血清样本,采用酶联免疫吸附试验(ELISA)法检测血清百日咳毒素IgG抗体(PT-IgG)。结果在1015名调查对象中,PT-IgG几何平均浓度(GMC)为4.35 IU/mL,抗体浓度低于检出限5 IU/mL的人数占58.2%,抗体阳性(抗体浓度≥100 IU/mL)率为2.4%。近1年内,百日咳感染(抗体浓度≥40 IU/mL)率排在前三位的年龄组为7~<10岁组(10.7%)、≥41岁组(9.9%)和5~<7岁组(8.3%)。不同性别间抗体浓度差异无统计学意义(Z=0.406,P>0.05),不同年龄组间抗体浓度差异有统计学意义(χ^(2)=53.639,P<0.05)。结论广州市健康人群百日咳抗体水平偏低。人群实际发病水平高于报告水平,存在漏报情况,尤其是≥41岁成年人和低年龄儿童。Objective To investigate the levels of antibody to pertussis in the healthy population in Guangzhou in 2019 and understand the potential infection of pertussis.Methods Serum samples were collected from healthy people of all ages in11 districts of Guangzhou by simple random sampling method.Serum IgG antibody against pertussis toxin(PT-IgG)were determined by enzyme-linked immunosorbent assay(ELISA).Results Of the 1015 subjects,the geometric mean concentration(GMC)of PT-IgG was 4.35 IU/mL,the proportion of people whose antibody concentration was lower than the detection limit of 5 IU/mL accounted for 58.2%,and the rate of antibody positive(antibody concentration≥100 IU/mL)was2.4%.In the past year,the top three age groups with pertussis infection(antibody concentration≥40 IU/mL)were 7-<9years old group(10.7%),≥41 years old group(9.9%)and 5-<7 years old group(8.3%).There was no statistically significant difference in antibody concentration between different genders(Z=0.406,P>0.05),and the difference in antibody concentration between different age groups was statistically significant(χ^(2)=53.639,P<0.05).Conclusion sThe level of pertussis antibodies in healthy people in Guangzhou was low.The actual incidence of the population was higher than the reported level,especially for adults≥41 years old and low-age children.

关 键 词：百日咳 抗体 健康人群 

分 类 号：R516.6[医药卫生—内科学]