结核分枝杆菌早期抗原分泌靶6研究进展  

Research progress of Mycobacterium tuberculosis early antigen secretion target 6

作　　者：刘玫肖 范雨鑫 陈晶晶 徐鑫 张宇 曹文静[1,3] 岳鹏 周国忠 宝福凯 柳爱华 LIU Mei-xiao;FAN Yu-xin;CHEN Jing-jing;XU Xin;ZHANG Yu;CAO Wen-jing;YUE Peng;ZHOU Guo-zhong;BAO Fu-kai;LIU Ai-hua(Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities,Kunming Medical University,Kunming,Yunnan 650500,China;Department of Microbiology and Immunology,Kunming Medical University,Kunming,Yunnan 650500,China;Department of Biochemistry and Molecular Biology,Kunming Medical University,Kunming,Yunnan 650500,China)

机构地区：[1]昆明医科大学云南省高校热带传染病重点实验室,云南昆明650500 [2]昆明医科大学病原生物学与免疫学系,云南昆明650500 [3]昆明医科大学生物化学与分子生物学系,云南昆明650500

出　　处：《热带医学杂志》2022年第10期1444-1449,共6页Journal of Tropical Medicine

基　　金：国家自然科学基金(32060180,81860644,81560596,31560051);云南省自然科学基金[2019FE001-(002),2017FE467-(001)]

摘　　要：结核分枝杆菌早期抗原分泌靶6(ESAT-6)是结核分枝杆菌基因组RD1区基因编码的分泌蛋白,ESAT-6可在细胞膜表面形成孔道导致吞噬体破裂从而介导结核分枝杆菌的免疫逃逸。同时,可用ESAT-6作为抗原进行γ-干扰素释放试验对结核病进行特异性诊断。除此,还探究了ESAT-6在亚单位疫苗中的发展问题,讨论了ESAT-6的作用以及作为亚单位疫苗的可行性。通过对ESAT-6的深入研究,为结核病的防治提供新的方法和思路。Mycobacterium tuberculosis early secreted antigenic target 6(ESAT-6)is a secreted protein encoded by in the region of difference 1(the region of difference 1)of Mycobacterium tuberculosis genome.ESAT-6 can form pores on host cell membrane surface and cause phagosome rupture of host phagocytes,and mediating the immune escape of Mycobacterium tuberculosis.At the same time,ESAT-6 can be used as an antigen to perform aγ-interferon release test for specific diagnosis of tuberculosis.In addition,this review also summarized the development of ESAT-6 in subunit vaccines,the role of ESAT-6 and its feasibility as a subunit vaccine.The in-depth research on ESAT-6 will provide new methods and ideas for the prevention and treatment of tuberculosis.

关 键 词：结核分枝杆菌 ESAT-6 免疫学诊断 疫苗 

分 类 号：R52[医药卫生—内科学]