血清GH、IGF-1与2型糖尿病患者合并视网膜病变的相关性  

Correlation between serum GH,IGF-1 and retinopathy in type 2 diabetic patients

作　　者：邢淑清[1] 尹雨婷 董玲玲 王新玲[1] 郭艳英[1] XING Shu-qing;YIN Yu-ting;DONG Ling-ling;WANG Xin-ling;GUO Yan-ying(Department of Endocrinology,People's Hospital of Xinjiang Uygur Autonomous Region,Xinjiang Clinical Research Center for Diabetes,Urumqi,Xinjiang 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院内分泌科,新疆糖尿病临床医学研究中心,新疆乌鲁木齐830001

出　　处：《热带医学杂志》2022年第10期1410-1413,1430,共5页Journal of Tropical Medicine

基　　金：新疆维吾尔自治区自然科学基金(2020D01C114)

摘　　要：目的探讨血清生长激素(GH)、胰岛素样生长因子-1(IGF-1)与2型糖尿病(T2DM)患者合并视网膜病变的相关性。方法选取2019年1-12月在新疆维吾尔自治区人民医院内分泌科住院的T2DM患者80例,根据是否合并视网膜病变分为非视网膜病变组(对照组)42例,视网膜病变组(病例组)38例。分别测定两组GH、IGF-1、空腹血糖、餐后2 h血糖、甘油三酯、总胆固醇、低密度脂蛋白、高密度脂蛋白、C反应蛋白、糖化血红蛋白水平。比较两组间各变量的差异,分析血清GH、IGF-1水平与T2DM患者合并视网膜病变之间的相关性。结果病例组年龄、病程、腹围水平均高于对照组,而体重、体重指数水平低于对照组,差异均有统计学意义(P均<0.05)。病例组餐后2h血糖水平、糖化血红蛋白、总胆固醇、C反应蛋白、IGF-1、GH水平均高于对照组,差异均有统计学意义(P均<0.05)。IGF-1水平与年龄(r=0.338)、糖化血红蛋白(r=0.328)、病程(r=0.202)均成正相关(P均<0.05);GH水平与病程(r=0.317)、空腹血糖(r=0.412)成正相关(P均<0.05)。年龄、病程、糖化血红蛋白和IGF-1与糖尿病视网膜病变独立相关。结论糖化血红蛋白、年龄、病程是糖尿病视网膜病变的独立危险因素。血清IGF-1水平偏高也与糖尿病视网膜病变有关,可将抑制IGF-1水平作为治疗糖尿病视网膜病变的途径之一。Objective The aim of this study was to investigate the correlation of diabetic retinopathy in type 2 diabetes patients and growth hormone(GH),insulin like growth factor-1(IGF-1).Methods A total of 80 T2DM patients hospitalized in the Department of Endocrinology,Xinjiang Uygur Autonomous Region People’s Hospital from January to December 2019 were selected.According to the presence or absence of retinopathy,the patients were divided into nonretinopathy group(control group,n=42)and retinopathy group(case group,n=38).The levels of GH,IGF-1,fasting blood glucose,2 h postprandial blood glucose,triglyceride,total cholesterol,low density lipoprotein,high density lipoprotein,C-reactive protein and HbA1c in the two groups were measured.The differences of each variable between the two groups were compared,and the correlation between serum GH and IGF-1 levels and retinopathy in T2DM patients was analyzed.Results The age,course of disease and abdominal circumference of the case group were higher than those of the control group,while the body weight and body mass index(BMI)of the case group were lower than those of the control group,and the differences were statistically significant(P<0.05).The 2 h postprandial blood glucose level,glycosylated hemoglobin,total cholesterol,C-reactive protein,IGF-1 and GH levels in the case group were higher than those in the control group,and the differences were statistically significant(P<0.05).IGF-1 level was positively correlated with age(r=0.338),HbA1c(r=0.328)and disease duration(r=0.202)(P<0.05).GH level was positively correlated with disease duration(r=0.317)and fasting blood glucose(r=0.412)(P<0.05).Age,disease duration,HbA1c and IGF-1 were independently associated with DR.Conclusions Glycated hemoglobin,age and disease duration were independent risk factors for diabetic retinopathy.High serum IGF-1 level was also associated with diabetic retinopathy.Inhibition of IGF-1 might be considered as one of the ways to treat diabetic retinopathy.

关 键 词：2型糖尿病 视网膜病变 生长激素 胰岛素样生长因子-1 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]