Npt和IP-10水平对中重度颅脑外伤预后评估的价值  

The value of Npt and IP-10 expression in the prognosis evaluation of moderate and severe traumatic brain injury

作　　者：袁明忠[1] 陈自强[1] 唐霞 叶锋[2] YUAN Ming⁃zhong;CHEN Zi⁃qiang;TANG Xia;YE Feng(Department of Neurosurgery,Rongxian People's Hospital,Zigong,Sichuan 643100;Department of Neurosurgery,Deyang People's Hospital,Deyang,Sichuan 618000,China)

机构地区：[1]荣县人民医院神经外科,四川自贡643100 [2]德阳市人民医院神经外科,四川德阳618000

出　　处：《热带医学杂志》2022年第6期818-821,841,共5页Journal of Tropical Medicine

基　　金：四川省科技支撑计划项目(2016SZ0015)

摘　　要：目的探讨血清新喋呤(Npt)、γ-干扰素诱导蛋白10(IP⁃10)水平对中重度颅脑外伤患者预后的评估价值。方法选取2017年2月-2020年10月荣县人民医院收治的175例颅脑外伤患者进行研究,按格拉斯哥昏迷评分(GCS)将其分为重度组(n=43)、中度组(n=67)、轻度组(n=65),并纳入同期65名体检健康者为对照组。以格拉斯哥预后评分(GOS)为4~5分和1~3分将颅脑外伤患者分为预后良好组(n=52)和预后不良组(n=58)。分析影响中重度颅脑外伤预后的因素及血清Npt、IP⁃10水平对中重度颅脑外伤患者预后的预测价值。结果轻度、中度、重度组患者血清Npt、IP⁃10水平高于对照组,且重度组高于中度组、轻度组,中度组高于轻度组,差异均有统计学意义(P均<0.05)。预后不良组患者高血压占比、血清Npt、IP⁃10水平高于预后良好组,差异均有统计学意义(χ^(2)/t=5.798、8.214、8.324,P均<0.05)。高血压、Npt、IP⁃10是影响中重度颅脑外伤不良预后的危险因素(P<0.05)。血清Npt、IP⁃10水平联合预测中重度颅脑外伤患者预后不良的曲线下面积(AUC)为0.929,其敏感度、特异度分别为90.4%、86.2%。结论中重度颅脑外伤患者血清Npt、IP⁃10水平较高,检测血清Npt、IP⁃10水平可辅助评估患者预后情况,且两者联合可更好地预测中重度颅脑外伤患者预后。Objective To investigate the value of serum Neopterin(Npt)and interferon-γinducible protein 10(IP-10)levels in evaluating the prognosis of patients with moderate to severe craniocerebral trauma.Methods A total of 175patients with craniocerebral trauma diagnosed and treated in Rongxian People’s Hospital from February 2017 to October2020 were selected for the study.According to the Glasgow coma scale(GCS)score,they were divided into severe group(n=43),moderate group(n=67),and mild group(n=65),and another 65 healthy people underwent physical examination during the same period were selected as the control group.The patients with traumatic brain injury were grouped into a good prognosis group(n=52,4-5 points)and a poor prognosis group(n=58,1-3 points)according to the Glasgow outcome scale(GOS)score.The factors affecting the prognosis of moderate to severe craniocerebral trauma and the predictive value of serum levels of Npt and IP-10 on the prognosis of patients with moderate to severe craniocerebral trauma were analyzed.Results The serum levels of Npt and IP-10 in the mild,moderate and severe groups were higher than those in the control group,and the severe group was higher than the moderate group and mild group,and the moderate group was higher than the mild group,and the differences were statistically significant(P all<0.05).The proportion of hypertension and serum levels of Npt and IP-10 in the poor prognosis group were higher than those in the good prognosis group(χ^(2)/t=5.798,8.214,8.324,P all<0.05).Hypertension,Npt and IP-10 were risk factors affecting the prognosis of moderate to severe craniocerebral trauma(P<0.05).The area under the curve(AUC)for predicting the poor prognosis of patients with moderate and severe craniocerebral trauma was 0.929,and its sensitivity and specificity were 90.4%and 86.2%,respectively.Conclusions The serum levels of Npt and IP-10 were relatively high in patients with moderate to severe craniocerebral trauma.The detection of serum levels of Npt and IP-10 could assist in evaluat

关 键 词：新喋呤 γ-干扰素诱导蛋白10 颅脑外伤 预后 

分 类 号：R651.15[医药卫生—外科学]