山东某医院患者乙型肝炎核心抗体阳性特征分析  

Analysis of positive characteristics of hepatitis B core antibody of patients in a hospital in Shandong

作　　者：韩群啸 许丽[2] 鲍国林 刘义庆 HAN Qun-xiao;XU Li;BAO Guo-lin;LIU Yi-qing(Department of Clinical Laboratory,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,Shandong Province,China;不详)

机构地区：[1]山东第一医科大学附属省立医院临床检验医学部,山东济南250021 [2]山东大学第二医院感染/肝病科,山东济南250033

出　　处：《微生物学免疫学进展》2022年第6期52-57,共6页Progress In Microbiology and Immunology

基　　金：山东省自然科学基金(ZR2020MH316)。

摘　　要：目的了解2016—2020年山东某医院就诊患者乙型肝炎核心抗体(core antibody against hepatitis B,HBcAb)分布特征及乙型病毒性肝炎(viral hepatitis type B,简称乙型肝炎)感染现状。方法用电化学发光免疫分析法(electrochemi-luminescence immunoassay)对采集的257922份血清样本进行乙肝五项检测,并对HBcAb阳性样本的时间、性别、年龄及乙肝五项不同组合模式的特征进行分析。结果人群中乙型肝炎病毒(hepatitis b virus,HBV)核心抗体(core antibody against hepatitis B,HBcAb)阳性有102598例,阳性率为39.78%;2020年阳性例数最多而阳性率最低,阳性率总体呈现逐年下降的趋势,时间差异有统计学意义(χ^(2)=122.74,P<0.05);男性阳性率高于女性,性别差异有统计学意义(P<0.05);>70岁组阳性率最高为66.38%,不同年龄组阳性率差异有统计学意义(χ^(2)=19272.47,P<0.05);模式10(HBsAb+HBcAb)的阳性最多,有39661例,阳性率为38.66%。结论表明乙型肝炎防控工作取得积极的效果。为减少HBV的感染,须对男性、老年人群、孕妇HBV携带者及乙型肝炎病例家庭成员等高危人群进行重点监控、防治,继续加强接种加强针、提高接种率或补种等方面工作。Objective To understand the distribution characteristics of core antibody against hepatitis B(HBcAb)and the infection status of viral hepatitis B(HBV)in a Shandong Provincial Hospital from 2016 to 2020.Methods Five items of hepatitis B were detected in 257922 serum samples by electrochemi-luminescence immunoassay.The characteristics of time,sex,age and the different combination modes of five items of hepatitis B were analyzed respectively in HBcAb positive samples.Results 102598 cases(39.78%)of hepatitis B virus(HBV)core antibody against hepatitis B(HBcAb)were positive.In 2020,the number of positive cases was the highest and the positive rate was the lowest(38.27%).The positive rate showed a reduced trend year by year,and the time difference was statistically significant(χ^(2)=122.74,P<0.05).The positive rate of male was higher than that of female,and the gender difference was statistically significant(P<0.05).The highest positive rate was 66.38%in the>71 years old group,and the difference was statistically significant in different groups(χ^(2)=19272.47,P<0.05).The positive rate of mode 10(HBsAb+HBcAb)was highest(38.66%).Conclusion The local prevention and control of hepatitis B has achieved positive results.In order to reduce HBV infection,it is necessary to focus on monitoring and prevention of high-risk groups such as men,elderly people,pregnant women with HBV carriers and family members of hepatitis B cases,and continue to strengthen boost vaccination,increasing the rate of vaccination or reseeding.

关 键 词：乙型病毒性肝炎 乙肝病毒 乙肝病毒核心抗体 乙肝五项 电化学发光免疫分析法 

分 类 号：R512.62[医药卫生—内科学]