NDM-1对阴沟肠杆菌的致病性及适应性的影响  

Impact of NDM-1 on pathogenicity and fitness of enterobacter cloacae

作　　者：代鹏飞(综述)[1] 杜艳(审校)[1] DAI Peng-fei;DU Yan(Yunnan Key Laboratory of Laboratory Medicine,Yunnan Institute of Laboratory Diagnosis,Department of Laboratory Medicine of the First Affiliated Hospital of Kunming Medical University,Kunming 650032,Yunnan Province,China)

机构地区：[1]昆明医科大学第一附属医院检验科,中国云南省检验医学重点实验室,云南昆明650032

出　　处：《微生物学免疫学进展》2020年第3期84-88,共5页Progress In Microbiology and Immunology

基　　金：云南省应用基础研究计划重点项目(2018FA043);云南省应用基础研究计划联合专项2019FE001(-060)

摘　　要：产生新德里金属β-内酰胺酶-1(New delhi metallol-β-lactamase 1,NDM-1)的肠杆菌科细菌对大部分β-内酰胺抗生素耐药,其导致的感染难以治疗。细菌中编码NDM-1基因的获得可能会影响它的致病性和适应性,这可能使产NDM-1的细菌的感染治疗和传播更加复杂。产NDM-1阴沟肠杆菌流行率高,现对阴沟肠杆菌的致病过程以及NDM-1对其致病性和适应性的影响作一概述,为产NDM-1阴沟肠杆菌的感染治疗和传播控制提供应对策略。NDM-1-producing enterobacteriaceae are resistant to mostβ-lactam antibiotics,and the infections are difficult in treatment.The acquisition of a gene encoding NDM-1 in bacteria may affect its pathogenicity and fitness,as a result it may make the treatment and transmission of NDM-1-producing bacteria more complicated.NDM-1-producing enterobacter cloacae has a high prevalence.This paper focuses on the pathogenic process of enterobacter cloacae and the effects of NDM-1 on its pathogenicity and fitness.It provides strategies in treatment of infection and control of transmission from NDM-1-producing enterobacter cloacae.

关 键 词：新德里金属β-内酰胺酶-1 阴沟肠杆菌 适应性 致病性 

分 类 号：R378[医药卫生—病原生物学]