脂联素水平与肥胖对多囊卵巢综合征患者体外受精胚胎移植术结局的影响  

Effects of the adiponectin level and obesity on in vitro fertilization and embryo transfer outcome in patients with polycystic ovary syndrome

作　　者：安锦霞[1] 刘小玲[1] 王琰[1] 倪亚莉[1] 贺清[1] 杨杰[1] An Jin-xia;Liu Xiao-ling;Wang Yan;Ni Ya-li;He Qing;Yang Jie(Center of Reproductive Medicine,Gansu Provincial Maternity and Child-Care Hospital,Lanzhou 730050,China)

机构地区：[1]甘肃省妇幼保健院生殖医学中心,甘肃兰州730050

出　　处：《兰州大学学报（医学版）》2018年第6期31-34,共4页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省自然科学基金项目(1506RJZA160);兰州市科技局卫生专项基金项目(2016-2-51).

摘　　要：目的探讨脂联素(ADPN)与多囊卵巢综合征(PCOS)患者的关系及其对体外受精胚胎移植术(IVF-ET)结局的影响。方法PCOS组患者120例,对照组患者100例。2组分别按照体重指数再分为2个亚组。检测患者月经周期第2天血清ADPN质量浓度,观察其与PCOS患者各代谢及生殖内分泌激素指标的关系及其对IVF-ET结局的影响。结果与对照组比较,ADPN质量浓度在PCOS组明显降低,并且在肥胖PCOS亚组降低更显著(P<0.05)。PCOS组内比较,肥胖PCOS亚组临床妊娠率低于非肥胖PCOS亚组,早期流产率高于非肥胖PCOS亚组,差异具有统计学意义(P<0.05)。结论PCOS患者血清ADPN水平较低,且肥胖PCOS患者更低,与IVF-ET结局不良相关。Objective To study the relationship between adiponectin(ADPN)and polycystic ovary syndrome(PCOS)and its impact on the outcome of in vitro fertilization and embryo transfer(IVF-ET)cycles.Methods 120 patients in PCOS group and 100 patients in control group.The two groups were divided into subgroups according to body mass index.ADPN levels were measured in serum on the menstrual cycle day 2,to observe the relationship between ADPN levels and glycolipid metabolism and reproductive endocrine hormones in patients with PCOS and its effect on IVF-ET outcome.Results The level of ADPN decreased significantly in the two PCOS groups and decreased more significantly in the obese PCOS subgroup(P<0.05).The clinical pregnancy rate of the obese PCOS subgroup was lower than that of the non-obese PCOS subgroup,the early abortion rate was higher than that of the non-obese PCOS subgroup(P<0.05).Conclusion Serum ADPN level was low in PCOS patients,and in obese PCOS patients especially,which was associated with poor IVF-ET outcome.

关 键 词：脂联素 多囊卵巢综合征 体外受精胚胎移植术 临床妊娠率 

分 类 号：R711.75[医药卫生—妇产科学] R714.8[医药卫生—临床医学]