疏肝清脂汤对糖尿病合并血脂异常患者糖脂代谢指标、氧化应激水平及微炎症状态的影响  

Effect of Shugan Qingzhi Decoction(疏肝清脂汤)on Glucose and Lipid Metabolism Index,Oxidative Stress Level and Micro-inflammatory State in Diabetic Patients with Dyslipidemia

作　　者：山峰 胡楠 SHAN Feng;HU Nan(Benxi Hospital of Traditional Chinese Medicine,Benxi 117000,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]本溪市中医院,辽宁本溪117000 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医杂志》2022年第3期149-153,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)(2013CB532004);辽宁省教育厅一般项目(L201907)

摘　　要：目的探讨疏肝清脂汤对糖尿病合并血脂异常患者糖脂代谢指标、氧化应激水平及微炎症状态的影响。方法参照纳、排标准,筛选该院2019年6月—2020年10月期间收治的患者,最终共入组112例糖尿病合并血脂异常患者,签订同意书,汇总信息后予随机分两组,各56例,对照组予常规治疗,治疗组加服疏肝清脂汤,治疗周期均为2个月。两组以糖脂代谢指标、氧化应激指标、炎症指标及中医证候积分作为观察指标,观察并比较患者糖脂代谢、氧化应激反应、微炎症状态及中医症状的变化情况,对比两组临床疗效。结果两组患者咽干口燥、情志不畅、胁肋胀满等中医症状均明显减轻,中医证候积分呈下降趋势(P<0.05),且治疗组变化趋势更显著(P<0.05);两组治疗后血糖、血脂指标均较前改善明显,且治疗组各指标改善更显著(P<0.05);两组治疗后超氧化物歧化酶(SOD)、8-羟基脱氧鸟苷(8-OHdG)、丙二醛(MDA)等氧化应激指标均较前有所改善(P<0.05),且组间比较,治疗组SOD升高更明显,8-OHdG、MDA下降更显著(P<0.05);两组治疗后C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)等炎症指标均较前呈下降趋势,且治疗组各指标下降趋势更明显(P<0.05);治疗组临床总有效率为85.71%(48/56),对照组临床总有效率为64.29%(36/56),治疗组的临床疗效优于对照组(P<0.05)。结论疏肝清脂汤可能是通过维持氧化/抗氧化系统平衡、抑制炎症反应的作用机制对糖尿病合并血脂异常患者进行治疗,从而调节糖脂代谢,减少氧化应激反应,消除炎症,发挥疏肝理气、化浊清脂的功效,临床值得应用。Objective To explore the effect of Shugan Qingzhi Decoction(疏肝清脂汤)on glucose and lipid metabolism index,oxidative stress level and micro-inflammatory state in diabetic patients with dyslipidemia.Methods Combined with the inclusion criteria and exclusion criteria,the diabetic patients with dyslipidemia diagnosed and treated in the hospital from June 2019 to October 2020 were screened,and 112 cases were finally included.All patients were randomly divided into two groups(group A and group B)according to the random number table method,each with 56 cases.The group A(control group)was given conventional western medicine treatment(Scheme A)and the group B(treatment group)was treated with Shugan Qingzhi Decoction on the basis of the Scheme A(Scheme B).The treatment course was 2 months.The change of TCM syndrome integral,the changes of levels of glucose and lipid metabolism index,oxidative stress index and inflammation index before and after treatment,and the clinical efficacy of the two groups were compared.Results After treatment,the TCM symptoms such as dry mouth and throat,gloomy mood and excessive phlegm were improved in both groups.The TCM syndrome scores of the two groups showed a downward trend(P<0.05),and the change trend of the group B was more significant(P<0.05).The indexes of blood glucose and blood lipid in the two groups were significantly improved,and the improvement of each index in the group B was more significant(P<0.05).The levels of oxidative stress indicators such as SOD,8-OHdG and MDA were increased significantly(P<0.05).Compared with that in the group A,the SOD level in the group B was increased significantly,and the levels of 8-OHdG and MDA were decreased significantly(P<0.05).After treatment,CRP,TNF-α,IL-6 and other inflammatory indicators in the two groups showed a downward trend,and the downward trend of each indicator level in the group B was more obvious(P<0.05).According to the total clinical effective rate,the clinical efficacy of group B(94.64%,48/56)was significantly better tha

关 键 词：疏肝清脂汤 糖尿病 血脂异常 糖脂代谢 氧化应激水平 微炎症状态 

分 类 号：R259[医药卫生—中西医结合]