室内空气污染与人群尿8-羟基脱氧鸟苷相关性研究进展  

Advances on association between indoor air pollution and 8-hydroxydeoxyguanosine in human urine

作　　者：石金刚 贺淼[1,2] SHI Jingang;HE Miao(School of Public Health,China Medical University,Shenyang,Liaoning 110122,China;Liaoning Provincial Key Laboratory of Environmental Health Damage Research and Assessment,China Medical University,Shenyang,Liaoning 110122,China)

机构地区：[1]中国医科大学公共卫生学院,辽宁沈阳110122 [2]中国医科大学辽宁省环境健康损害研究与评价重点实验室,辽宁沈阳110122

出　　处：《环境与职业医学》2022年第4期465-469,共5页Journal of Environmental and Occupational Medicine

基　　金：辽宁省自然科学基金重点项目(20170541038)

摘　　要：尿8-羟基脱氧鸟苷(8-OHdG)是反映机体氧化应激及DNA氧化损伤的标志物。人一生有80%~90%的时间在室内度过,室内空气质量直接关系到人体健康。本文介绍了不同人口特征、生活方式、职业暴露、健康状态的人群尿8-OHdG水平,阐述了影响人群尿8-OHdG浓度的室内空气污染因素,包括室外来源的污染物、吸烟、室内燃烧及烹调油烟、室内装修材料中的化学物质、建筑物地基。通过测定人群尿8-OHdG浓度,为推测室内空气污染对人群健康的影响(DNA氧化损伤和相关疾病)提供理论依据。8-hydroxydeoxyguanosine(8-OHdG)in human urine is a marker reflecting oxidative stress and DNA oxidative damage.People spend 80%-90%of their life indoors;therefore,indoor air quality is directly related to human health.In this paper,the urinary 8-OHdG levels were presented in populations grouped by different demographic characteristics,lifestyle,occupational exposure,and health status,and elucidated indoor pollutants affecting human urinary 8-OHdG level,such as pollutants from outdoor sources,smoking,indoor combustion and cooking fumes,the chemicals in interior decoration materials,and building foundation soils.The article aims to provide a theoretical basis for predicting the impact of indoor air pollution on human health(DNA oxidative damage and related diseases)by measuring the concentration of8-OHdG in human urine.

关 键 词：室内空气污染 8-羟基脱氧鸟苷 DNA氧化损伤 健康损害 

分 类 号：R122.26[医药卫生—环境卫生学]