健康老年人短期空气污染暴露与体力活动对神经损伤的影响  

Effects of short-term air pollution exposure and physical activity on neural damage in the elderly

作　　者：瞿蓉蓉 孙家官 孙贝贝 王亚 安珍[1] 吴卫东[1] 宋杰 QU Rongrong;SUN Jiaguan;SUN Beibei;WANG Ya;AN Zhen;WU Weidong;SONG Jie(School of Public Health,Xinxiang Medical University,Xinxiang,Henan 453003,China)

机构地区：[1]新乡医学院公共卫生学院,河南新乡453003

出　　处：《环境与职业医学》2022年第4期391-396,共6页Journal of Environmental and Occupational Medicine

基　　金：河南省科技攻关计划(222102310600)

摘　　要：[背景]越来越多的证据表明空气污染对健康的损害以及体力活动对健康的益处,而空气污染和体力活动对神经系统的影响需要更多研究。[目的]探究短期空气污染暴露与体力活动对健康老年人神经损伤生物标志的影响。[方法]采用定组研究方法,在新乡医学院招募身心健康的退休职工,于2018年12月至2019年4月定期进行5次随访。使用问卷获取人口学特征及体力活动信息,根据体力活动强度和时间计算每周的体力活动水平。检测血清中神经损伤生物标志包括脑源性神经营养因子(BDNF)、神经丝轻链(NF-L)、神经元特异性烯醇化酶(NSE)、蛋白基因产物9.5(PGP9.5)和钙结合蛋白S100B(S100B)的浓度。同时收集空气污染数据(包括PM_(2.5)、PM_(10)、O^(3)、SO^(2)、CO、NO^(2))。采用广义估计方程分析空气污染物浓度、体力活动水平与神经损伤生物标志浓度的关系。[结果]研究共纳入29名志愿者,年龄(63.5±5.89)岁;男性11人,占比37.93%;初中以上文化程度占半数以上(62.07%),体力活动水平为(80.23±54.51)MET-h·周^(-1)。研究期间PM_(2.5)、PM_(10)、O^(3)、SO^(2)、CO、NO^(2)的日均质量浓度分别为(68.27±60.98)μg·m^(-3)、(130.57±58.71)μg·m^(-3)、(36.86±13.89)μg·m^(-3)、(17.86±10.59)μg·m^(-3)、(4.94±1.34)mg·m^(-3)和(50.83±8.03)μg·m^(-3)。血清BDNF、NF-L、NSE、PGP9.5和S100B的质量浓度分别为(139.12±46.71)μg·L^(-1)、(402.60±183.31)ng·L^(-1)、(11.26±10.32)ng·L^(-1)、(14.32±13.57)ng·L^(-1)和(127.57±41.74)ng·L^(-1)。广义估计方程分析结果表明,较高浓度的PM_(2.5)和O^(3)与血清中NSE浓度增加有关(OR=1.359,95%CI:1.224~1.509,P<0.001;OR=1.286,95%CI:1.076~1.537,P=0.006),而较高浓度的NO^(2)与NSE浓度降低有关(OR=0.692,95%CI:0.549~0.873,P=0.002);较高浓度的O^(3)和SO^(2)与血清中NF-L浓度降低有关(OR=0.855,95%CI:0.740~0.989,P=0.035;OR=0.813,95%CI:0.700~0.946,P=0.007);较高浓度的NO^(2)与血清中PGP9.5�[Background]Emerging evidence has shown the damage of air pollution and the benefits of physical activity to human health,and the effects of air pollution and physical activity on the nervous system need more research.[Objective]To explore the effects of short-term air pollution exposure and physical activity on neural damage biomarkers in healthy elderly.[Methods]Using a design of panel study,physically and mentally healthy retired employees were recruited from Xinxiang Medical University,and were followed up five times regularly from December 2018 to April 2019.The demographic characteristics and physical activity information were obtained by questionnaire,and the weekly physical activity level was calculated according to intensity and duration of physical activity.Biomarkers of neural damage in serum were measured,including brain-derived neurotrophic factor(BDNF),neurofilament light chain(NF-L),neuron specific enolase(NSE),protein gene product 9.5(PGP9.5),and S100 calcium-binding protein B(S100 B).Air pollution data(including PM_(2.5),PM_(10),O^(3),SO^(2),CO,and NO^(2))of the follow-up period were collected.Generalized estimation equation was used to analyze the association of air pollution concentration and physical activity level with the concentration of neural damage biomarkers.[Results]A total of 29 volunteers were included in the study,with an average age of(63.5±5.9)years;there were 11 men accounting for37.93%;more than half of them(62.07%)received above junior middle school education;the mean physical activity level was(80.23±54.51)MET-h·week^(-1).The daily average concentrations of PM_(2.5),PM_(10),O^(3),SO^(2),CO,and NO^(2)during the study period were(68.27±60.98)μg·m^(-3),(130.57±58.71)μg·m^(-3),(36.86±13.89)μg·m^(-3),(17.86±10.59)μg·m^(-3),(4.94±1.34)mg·m^(-3),and(50.83±8.03)μg·m^(-3),respectively.The average serum concentrations of BDNF,NF-L,NSE,PGP9.5,and S100 B were(139.12±46.71)μg·L^(-1),(402.60±183.31)ng·L^(-1),(11.26±10.32)ng·L^(-1),(14.32±13.57)ng·L^(-1),and(127.

关 键 词：空气污染 短期暴露 体力活动 神经损伤 生物标志 

分 类 号：R114[医药卫生—卫生毒理学]