神经节苷脂联合安宫牛黄丸对急性重症颅脑损伤的临床疗效  

Clinical effect of ganglioside combined with Angong Niuhuang pill in treatment of acute severe craniocerebral injury

作　　者：秦杰[1] 黄道超 张闯[1] 蒋玭露 管琼婵 单仁飞[1] QIN Jie;HUANG Daochao;ZHANG Chuang;JIANG Pinlu;GUAN Qiongchan;SHAN Renfei(Department of Emergency,Taizhou Hospital of Zhejiang Province,TaiZhou 317000,China)

机构地区：[1]浙江省台州医院急诊科,台州317000

出　　处：《中国临床药学杂志》2022年第2期126-130,共5页Chinese Journal of Clinical Pharmacy

摘　　要：目的探讨神经节苷脂联合安宫牛黄丸对急性重症颅脑损伤的临床疗效。方法选择2018年1月至2019年12月就诊的急性重症颅脑损伤患者120例,按随机数字表法将其分为观察组和对照组,每组60例。在常规治疗基础上,对照组予单唾液酸四己糖神经节苷脂钠注射液100 mg,iv gtt,qd;观察组予单唾液酸四己糖神经节苷脂钠注射液100 mg,iv gtt,qd+安宫牛黄丸1丸,po,qd。2组疗程均为28 d。比较2组治疗前后神经功能缺损程度(NIHSS)和格拉斯哥昏迷指数(GCS)评分,血清神经元特异性烯醇化酶(NSE)、基质金属蛋白酶-2(MMP-2)、血管内皮生长因子(VEGF)水平、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)和白介素1β(IL-1β)水平;记录2组不良反应。结果2组患者治疗后NIHSS评分低于治疗前,而GCS评分高于治疗前(P<0.05);观察组患者治疗后NIHSS评分低于对照组,而GCS评分高于对照组(P<0.05)。2组患者治疗后血清NSE、MMP-2和VEGF水平均低于治疗前(P<0.05);观察组患者治疗后血清NSE、MMP-2和VEGF水平低于对照组(P<0.05)。2组患者治疗后血清CRP、TNF-α和IL-1β水平低于治疗前(P<0.05);观察组患者治疗后血清CRP、TNF-α和IL-1β水平低于对照组(P<0.05)。2组均未出现严重不良反应。结论神经节苷脂联合安宫牛黄丸可减轻重症急性颅脑损伤患者的神经功能缺损程度和炎症反应,降低NSE、MMP-2和VEGF水平。AIM To explore the clinical effect of ganglioside combined with Angong Niuhuang pill in the treatment of acute severe craniocerebral injury.METHODS A total of 120 patients with acute severe craniocerebra injury were selected from January 2018 to December 2019,and they were divided into observation group and control group,with 60patients in each group.On the basis of conventional treatment,the control group was treated with monosialotetrahexosylganglioside sodium injection 100 mg,iv gtt,qd;and the observation group was treated with Angong Niuhuang pill(1 pill,po,qd)on the basis of the control group.In both groups,14 d were used as a course of treatment,and two consecutive courses were treated.Scores of NIH Stroke Scale(NIHSS)and Glasgow coma scale(GCS),levels of serum neuron specific enolase(NSE),matrix metalloproteinase-2(MMP-2)and vascular endothelial growth factor(VEGF),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)were compared between 2 groups before and after treatment.Adverse reactions of 2 groups were recorded.RESULTS The NIHSS scores of 2 groups after treatment were lower than before treatment,while GCS scores were higher than before treatment(P<0.05);the NIHSS scores of observation group after treatment were lower than control group,while GCS scores were higher than control group(P<0.05).The serum NSE,MMP-2 and VEGF levels of 2 groups after treatment were lower than before treatment(P<0.05);the serum NSE,MMP-2 and VEGF levels of observation group after treatment were lower than control group(P<0.05).The serum CRP,TNF-αand IL-1βlevels of 2 groups after treatment were lower than before treatment(P<0.05);the serum CRP,TNF-αand IL-1βlevels of observation group after treatment were lower than control group(P<0.05).There were no serious adverse reactions in 2 groups.CONCLUSION Ganglioside combined with Angong Niuhuang pill in the treatment of patients with acute severe craniocerebra injury can not only reduce the degree of neurological deficit and the inflammatory react

关 键 词：神经节苷脂 安宫牛黄丸 重症急性颅脑损伤 

分 类 号：R651.15[医药卫生—外科学]