无骨质疏松的男性2型糖尿病患者视网膜病变与25羟维生素D的关系  

Association between diabetic retinopathy and 25-hydroxylvitamin D in male patients with type 2 diabetes mellitus without osteoporosis

作　　者：苏志燕[1] 刘薇[1] 史婷婷[1] 杨金奎[1] Su Zhiyan;Liu Wei;Shi Tingting;Yang Jinkui(Department of Endocrinology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院内分泌科,北京100730

出　　处：《临床内科杂志》2022年第2期101-103,共3页Journal of Clinical Internal Medicine

基　　金：白求恩公益基金资助项目(B-0307-H-20200302)

摘　　要：目的探讨无骨质疏松的男性2型糖尿病(T2DM)患者视网膜病变与25羟维生素D(25OHD)的关系。方法纳入256例无骨质疏松的男性T2DM患者进行分析,其中无糖尿病视网膜病变组(NDR)152例,合并非增殖期糖尿病视网膜病变组(NPDR)74例,增殖期糖尿病视网膜病变组(PDR)30例。比较3组患者的一般资料、实验室检查指标及25OHD水平;分析T2DM患者的25OHD营养情况,并对DR与25OHD水平的关系进行Pearson相关分析;采用logistic回归分析探讨DR的危险因素。结果NDR组、NPDR组、PDR组的25OHD水平依次下降[分别为(15.92±6.84)μg/L、(13.00±5.56)μg/L、(10.35±3.25)μg/L,P<0.05]。25OHD严重缺乏患者DR发生率显著高于其他组患者(P<0.05)。Pearson相关分析结果显示,DR与25OHD呈负相关(r=-0.305,P<0.001)。Logistic回归分析结果显示,25OHD和空腹C肽是DR的独立保护因素(P<0.05)。结论无骨质疏松的男性T2DM患者25OHD水平与DR相关,25OHD可能为DR的保护性因素。Objective To investigate the association between diabetic retinopathy and 25-hydroxylvitamin D(25 OHD)in male patients with type 2 diabetes mellitus(T2 DM)without osteoporosis.Methods A total of 256 patients with T2 DM were restrospective,152 cases had no diabetic retinopathy(NDR),74 cases had non-proliferative diabetic retinopathy(NPDR),30 cases had proliferative diabetic retinopathy(PDR).General information,biochemical and 25 OHD level of different DR groups were compared.The nutritional status of 25 OHD in patients with T2 DM were analyzed.The relationship between DR and 25 OHD level was analyzed by Pearson correlation analysis.Risk factor of DR was analyzed by logistic regression analysis.Results The levels of 25 OHD in NDR group,NPDR group and PDR group decreased in turn[(15.92±6.84)μg/L,(13.00±5.56)μg/L,(10.35±3.25)μg/L,P<0.05].The incidence of DR in severe deficiency 25 OHD group was significantly higher than those in other groups(P<0.05).Pearson correlation analysis showed that DR was negatively correlated with 25 OHD(r=-0.305,P<0.001).Logistic regression analysis showed that 25 OHD and fasting C-peptide were independent protective factors of DR(P<0.05).Conclusion 25 OHD is associated with DR in male T2 DM patients without osteoporosis,which maybe a potential protective factor for DR.

关 键 词：男性 2型糖尿病 糖尿病视网膜病变 25羟维生素D 

分 类 号：R587.2[医药卫生—内分泌] R580[医药卫生—内科学]