硅酸钙生物材料诱导牙源性干细胞成牙/成骨分化机制的研究进展  

Research progress of the mechanism of odonto/osteogenic differentiation of dental stem cells induced by calcium silicate cements

作　　者：周杨 李谨[1,3] 朱庆萍[1,3] 吴大明[1,2] ZHOU Yang;LI Jin;ZHU Qingping;WU Daming(Jiangsu Key Laboratory of Oral Diseases,Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学口腔疾病研究江苏省重点实验室,江苏南京210029 [2]南京医科大学附属口腔医院牙体牙髓病科,江苏南京210029 [3]南京医科大学附属口腔医院特诊科,江苏南京210029

出　　处：《口腔医学》2020年第2期169-175,共7页Stomatology

基　　金：江苏省自然科学基金面上项目(BK20151560);东南大学-南京医科大学合作研究项目(2018DN0015,2242018K30N15).

摘　　要：硅酸钙材料(calcium silicate cements,CSCs)是以硅酸三钙和硅酸二钙为主要成分的生物材料,具有良好的生物相容性、抗菌性、抗炎性、能促干细胞成牙/成骨分化,已被广泛应用于骨组织工程、牙科及整形外科等领域。近年来,以三氧化物聚合物(MTA)为代表的CSCs已被广泛应用于盖髓术、牙髓切断术、穿孔修补和根尖屏障等牙髓治疗中。纳米技术的应用显著提升了CSCs的理化性能、离子释放特征及生物学活性。CSCs可能是通过信号分子(如生长和分化因子)的激活/表达、与之应答的牙源性干细胞及微环境之间的相互作用促进骨和牙本质再生。该文将对CSCs诱导牙源性干细胞成牙/成骨分化的相关机制进行综述。Calcium silicate cements(CSCs)are biomaterials with tri-and di-calcium silicates as their dominant ingredients,which exhibit excellent biocompatibility,antibacterial and anti-inflammatory properties and can promote stem cells odonto/osteogenic differentiation.CSCs are widely used in bone tissue engineering,dentistry,plastic surgery and other fields.In recent years,MTA,a representative product of CSCs,has been widely applied in pulp capping,pulpotomy,perforation repairment,apical barriers and other endodontic treatments.Furthermore,the application of nanotechnology has significantly improved the physical and chemical properties,the ion release characteristics and bioactivity of CSCs.The interaction between signaling molecules(such as growth and differentiation factors)activation/expression,responsive dental stem cells and the microenvironment are considered as the possible mechanism underlying the promotion of odonto/osteogenic regeneration induced by CSCs.This article will review the related mechanism of CSCs on odonto/osteogenic differentiation of dental stem cells.

关 键 词：硅酸钙材料 牙源性干细胞 牙/骨生成 分子信号 

分 类 号：R318.08[医药卫生—生物医学工程]