阿尔茨海默病中Tau蛋白致病机理及其药物治疗研究进展  

Research progress on pathogenesis and drug therapy of Tau protein in Alzheimer’s disease

作　　者：马伟洋 薛鹏坤 高一盈 王珍[1] 董文霞 张娟[1] 张紫娟[1] 张振强[2] MA Weiyang;XUE Pengkun;GAO Yiying;WANG Zhen;DONG Wenxia;ZHANG Juan;ZHANG Zijuan;ZHANG Zhenqiang(School of Medical Science Henan University of Chinese Medicine Zhengzhou 450046,CHN;Academy of Chinese Medical Sciences,Henan University of Chinese Medicine,Zhengzhou 450046,CHN)

机构地区：[1]河南中医药大学医学院,郑州450046 [2]河南中医药大学中医药科学院,郑州450046

出　　处：《河南大学学报（医学版）》2023年第1期8-15,共8页Journal of Henan University:Medical Science

基　　金：中原千人计划-科技创新领军人才项目(204200510022);河南省科技攻关项目(202102310078,172102310286,212102310828,212102310314);河南省高校重点科研项目(19A310012,18B310004);河南省大学生创新训练项目(S202110471010);河南省高校科技创新团队支持计划资助(21IRTSTHN026)。

摘　　要：目的:综述近年来阿尔茨海默病(Alzheimer's disease,AD)中有关Tau蛋白的研究进展,阐明Tau蛋白与AD病理特征的关系,以期为AD病理机制研究和指导临床用药提供帮助。方法:以“AD”“Tau蛋白”“神经原纤维缠结”为关键词,通过PubMed、Web of Science及循证医学网查找相关文献。文献纳入标准:①Tau蛋白结构与功能的研究;②Tau蛋白致AD发病相关机制的研究;③以Tau蛋白为靶点AD治疗药物的研究。文献排除标准:结果相对陈旧或重复的实验研究。最终选择69篇文献纳入分析。结果:Tau蛋白与认知障碍的相关性比Aβ更强。结论:以Tau蛋白为靶点进行药物研发有望为AD治疗提供全新的视角。Objective:Review on the research progress of Tau protein in Alzheimer’s disease(AD)in recent years,and clarifies the relationship between Tau protein and the pathological characteristics of AD in order to provide help for the study of pathological mechanism of AD and the guidance of clinical medication.Methods:Taking“AD”“Tau protein”“neurofibrillary tangles”as keywords,we searched the relevant literatures through PubMed,Web of Science and Evidence-Based Medicine Network.Literatures inclusion criteria:①Study on the structure and function of Tau protein;②Study on the pathogenesis of AD caused by Tau protein;③Study on AD therapeutic drugs targeting Tau protein.Literatures exclusion criteria:Experimental studies with relatively old or repeated results.Finally,69 literatures were selected for analysis.Results:The correlation between Tau protein and cognitive impairment is stronger than that of Aβ.Conclusion:Development of drugs targeting Tau protein is expected to provide a new perspective for the treatment of AD.

关 键 词：阿尔茨海默病 TAU蛋白 神经原纤维缠结 研究进展 

分 类 号：R33[医药卫生—人体生理学]