不同移植失败次数后宫腔灌注重组人绒毛膜促性腺激素对冻融胚胎移植助孕结局的作用  

Effects of the intrauterine perfusion of recombinant hCG before a frozen-thawedembryo transfer in women with different implantation failure times

作　　者：李静[1] 张俊韦 乔洪武[1] 李真[1] 于晓娜[1] 张文[1] 管一春[1] LI Jing;ZHANG Junwei;QIAO Hongwu;LI Zhen;YU Xiaona;ZHANG Wen;GUAN Yichun(Reproductive Centre,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,CHN)

机构地区：[1]郑州大学第三附属医院生殖中心,郑州450052

出　　处：《河南大学学报（医学版）》2022年第5期358-363,共6页Journal of Henan University:Medical Science

基　　金：河南省医学科技攻关计划(LHGJ2018020199)

摘　　要：目的:探讨不同移植失败次数后宫腔灌注重组人绒毛膜促性腺激素(rhCG)对冻融胚胎移植助孕结局的作用。方法:回顾性分析2017年1月~2019年12月在某生殖中心行宫腔灌注rhCG的冻融胚胎移植(FET)患者的资料,按移植失败次数分为移植失败1次(A组)、2次(B组)、≥3次(C组)3组,比较患者的年龄、不孕年限、基础内分泌、移植胚胎个数、移植日内膜厚度等相关资料,分析研究宫腔灌注rhCG后的临床妊娠率、种植率、早期流产率、异位妊娠率、持续妊娠率、活产率等指标。结果:行宫腔灌注rhCG的FET周期共有182个周期,其中移植失败1次、2次、≥3次的周期数分别为90、60、32,A组不孕年限低于对照组,差异有统计学意义(P<0.05);B组移植胚胎数高于对照组,差异有统计学意义(P<0.05),C组与对照组两组患者基本资料差异无统计学意义(P>0.05);与对照组相比,A、B、C3组妊娠结局差异均无统计学意义(P>0.05)。结论:宫腔内灌注rhCG不能改善移植失败患者的助孕结局,不常规推荐移植前行宫腔灌注rhCG。Objective:To investigate the effects of the intrauterine perfusion of recombinant human chorionic gonadotropin(r-hCG)before frozen-thawedembryo transfer(FET)in women with differentimplantation failure times.Methods:The data of patients undergoing FET who received an intrauterine injection r-hCG 2000 IU before embryo transfer were retrospectively analysed between Jan.2017 and Dec.2019 in Reproductive Centre of the Third Affiliated Hospital of Zhengzhou University.There were three groups according to implantation failure times.The characteristics(patients’ages,basalendocrine,numember of embryos transfer,the endometrial thickness)and outcomes(the rate of clinical pregnancy,early abortion,implantation,live birth)were investigated.Results:There were 182 patients including first implantation failure(A group,n=90),second implantation failure(B group,n=60),and three or more times failures(C group,n=32).Duration of infertility in group A was significantly less than that of the control group(P<0.05),the number of embryos transfer in group B was more than that of the control group(P<0.05),there was no significant difference between group C and the control group(P>0.05).The outcomes of three groups conclude no statistical difference compared to the control groups.Conclusion:The outcomes were no improvement after the intrauterine perfusion of r-hCG before a frozen-thawed embryo transfer,and was not recommended.

关 键 词：移植失败 宫腔灌注 重组人绒毛膜促性腺激素 冻融胚胎移植 助孕结局 

分 类 号：R714.8[医药卫生—妇产科学]