CC10在下呼吸道慢性炎症性疾病中的作用研究进展  

Research progress of CC10 protein in chronic obstructive pulmonary disease and asthma

作　　者：徐爱茹 彭杨 陈诗颖 关伟杰[1] 王德云[2] Xu Ai-Ru;Peng Yang;Chen Shi-Ying;Guan Wei-Jie;Wang De-Yun(Department of Respiratory,the First Affiliated Hospital of Guangzhou Medical University/Guangzhou Institute of Respiratory Health/State Key Laboratory of Respiratory Disease,Guangzhou Medical University/National Clinical Research Center for Respiratory Disease,Guangzhou Medical University,Guangzhou 510120,China;Department of Otolaryngology,Yong Loo Lin School of Medicine,National University of Singapore,Singapore 119077,Singapore)

机构地区：[1]广州医科大学附属第一医院呼吸内科/广州呼吸健康研究院/广州医科大学呼吸疾病国家重点实验室/广州医科大学国家呼吸系统疾病临床医学研究中心,广州510120 [2]新加坡国立大学耳鼻咽喉头颈外科,新加坡119077

出　　处：《解放军医学杂志》2020年第2期158-161,共4页Medical Journal of Chinese People's Liberation Army

摘　　要：克拉拉细胞10-kD蛋白(CC10)是呼吸道分泌物中表达最丰富的蛋白之一,在免疫应答、抗感染和肺损伤修复中起重要作用。慢性阻塞性肺疾病和支气管哮喘是两种最常见的慢性下呼吸道炎症性疾病,其发病机制与CC10的异常表达密切相关。深入了解CC10的生物学特性,可为将来治疗呼吸道慢性炎症性疾病提供新的靶点。该文综述了CC10在下呼吸道慢性炎症性疾病中的研究进展。Clara cell 10-kD protein(CC10)is one of the most abundant proteins in the respiratory secretions,and plays an important role in immune response,anti-infection and lung injury repair.Chronic obstructive pulmonary disease and bronchial asthma are common chronic lower respiratory tract inflammatory diseases,the pathogenesis of which are intimately related to the abnormal expression of CC10.Therefore,an in-depth research of the biological characteristics of CC10 are helpful for exploring for the important targets for the treatment of chronic respiratory inflammatory diseases in the future.This review summarizes the current research progress in this field.

关 键 词：CC10 慢性阻塞性肺疾病 支气管哮喘 

分 类 号：R562.2+5[医药卫生—呼吸系统]