H7N9禽流感病毒跨种间传播及其感染人气道黏膜的分子机制研究进展  

Mechanisms of cross-species transmission of H7N9 avian influenza virus and its pathological features in airway epithelium: Research progress

作　　者：郭妍蓉 谈思怡 林宇静[3] 刘曦[4] 郑晓滨[5] 乔永康 Tan Kai Sen 王德云[7] 张评浒 严彦 Guo Yan-Rong;Tan Si-Yi;Lin Yu-Jing;Liu Xi;Zheng Xiao-Bin;Qiao Yong-Kang;Tan Kai Sen;Wang De-Yun;Zhang Ping-Hu;Yan Yan(Guangdong Key Laboratory of Biomedical Imaging,the Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,Guangdong 519000,China;Center for Infection and Immunology,the Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,Guangdong 519000,China;Department of Pathology,the Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,Guangdong 519000,China;Infectious Disease Center,the Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,Guangdong 519000,China;Department of Respiratory Medicine,the Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,Guangdong 519000,China;BGI Institute of Life Sciences,Shenzhen,Guangdong 518083,China 7Department of Otolaryngology,Yong Loo Lin School of Medicine,National University of Singapore,119077,Singapore;Institutes of Translational Medicine,Yangzhou University,Yangzhou,Jiangsu 225009,China)

机构地区：[1]中山大学附属第五医院广东省生物医学影像重点实验室,广东珠海519000 [2]中山大学附属第五医院感染与免疫学研究中心,广东珠海519000 [3]中山大学附属第五医院病理科,广东珠海519000 [4]中山大学附属第五医院感染病防治中心,广东珠海519000 [5]中山大学附属第五医院呼吸内科,广东珠海519000 [6]华大基因生命科学研究院,广东深圳518083 [7]新加坡国立大学杨潞龄医学院耳鼻喉头颈外科系,新加坡119077 [8]扬州大学转化医学研究院,江苏扬州225009

出　　处：《解放军医学杂志》2020年第2期139-149,共11页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金面上项目(81870019);广东省自然科学基金面上项目(2018A030313554);中山大学“百人计划”科研启动项目;江苏省人兽共患病学重点实验室开放课题(R1707).

摘　　要：H7N9型禽流感是一种新型的禽流感,2013年2月底在我国长三角地区率先暴发感染人的疫情。人感染的H7N9禽流感是由H7N9亚型禽流感病毒引起的急性呼吸道传染病,经呼吸道传播。由于种属屏障,禽流感病毒只在偶然的情况下可以感染人,且目前尚未发现H7N9禽流感病毒在人与人之间传播的确切证据。然而,H7N9禽流感已成为一种持续的公共卫生威胁,截至目前,中国已暴发了6次H7N9禽流感疫情,向WHO报告的H7N9禽流感病毒感染病例已有1567例,其中615例死亡。在H7N9禽流感病毒感染人体的过程中,呼吸道黏膜上皮细胞首当其冲,在病毒传播和感染过程中起关键作用。H7N9禽流感病毒如何跨越种属屏障造成人的感染,以及禽流感病毒感染宿主而导致的黏膜损伤诱发的免疫应答的分子机制,是该综述探讨的主要方向。H7N9 avian influenza is a new subtype of avian influenza,first found in the Yangtze River Delta at the end of February 2013.H7N9 avian influenza,infection in human is transmitted through the respiratory airway,causing acute respiratory infectious disease.Due to the species barrier,H7N9 avian influenza virus only infect human via birds occasionally under very specific circumstances,and at present,there is no exact evidence of H7N9 avian influenza virus transmission between humans.However,H7N9 avian influenza remains a continuous public health threat.So far,China has had six outbreaks of H7N9 avian influenza.A total of 1567 cases of H7N9 influenza virus infection have been reported to WHO,including 615 deaths.When H7N9 avian influenza virus infects the human body,their primary target of infection is the respiratory mucosal epithelial cells.Therefore,the respiratory epithelium plays a key role in the process of virus transmission and infection.Hence,the main purpose of this review is to collate the current understanding of immune responses and their corresponding molecular mechanisms of mucosal damage caused by H7N9 avian influenza infection,and how it contributes to cross species human infection.

关 键 词：H7N9禽流感病毒 跨种间传播 气道上皮细胞 免疫应答 炎症反应 

分 类 号：R373.1[医药卫生—病原生物学]