消疣颗粒、匹多莫德联合聚肌胞皮损内注射治疗扁平疣临床分析  

Clinical analysis of Xiaoyou Granule,pidotimod combined with intramuscular injection of polyinosinic-polycytidylic acid in treatment of flat wart

作　　者：郭忠梁 刘元媛[2] 孔伟 王国昌[1] 顾宇峰[4] Guo Zhong-liang;Liu Yuan-yuan;Kong Wei;Wang Guo-chang;Gu Yu-feng(Suining Central Hospital Department of Plastic and Burns,Suining 629000,China;Suining Central Hospital Department of Medical Cosmetology,Suining 629000,China;Zhuhai Municipal People's Medical Center Department of Dermatolog,Zhuhai 519000,China;Suining Central Hospital Department of Belief,Suining 629000,China)

机构地区：[1]遂宁市中心医院整形及烧伤外科,遂宁629000 [2]遂宁市中心医院医疗美容科,遂宁629000 [3]珠海市人民医院皮肤科,珠海519000 [4]遂宁市中心医院信息科,遂宁629000

出　　处：《湖南师范大学学报（医学版）》2020年第2期142-145,共4页Journal of Hunan Normal University(Medical Sciences)

摘　　要：目的:探讨消疣颗粒、匹多莫德联合聚肌胞皮损内注射治疗扁平疣临床疗效。方法:选择2014年2月~2017年2月我院接诊的120例扁平疣患者进行研究,通过随机数表法分为观察组(n=60)和对照组(n=60),对照组给予0.1%维A酸霜治疗,观察组在此基础上,联合消疣颗粒^+匹多莫德^+聚肌胞注射液治疗,两组均以4周为1个疗程,连续治疗2个疗程。比较两组临床疗效、治疗前后T淋巴细胞亚群(CD3^+、CD4^+、CD4^+/CD8^+)、白介素-6(Interleukins-6,IL-6)、干扰素-γ(Interferon-γ,IFN-γ),肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)的变化、不良反应及复发率。结果:治疗后,观察组临床疗效总有效率为96.67%(58/60),明显高于对照组的78.33%(47/60);治疗后,两组CD3^+、CD4^+、CD4^+/CD8^+较治疗前均显著升高,观察组CD3^+、CD4^+、CD4^+/CD8^+均明显高于对照组[(60.71±8.40)%vs(57.39±7.17)%,(40.84±5.31)%vs(36.18±5.06)%,(1.46±0.20)vs(1.27±0.19)];治疗后,两组IL-2、INF-γ较治疗前均显著升高,TNF-α显著降低,观察组IL-2、INF-γ明显高于对照组[(4.29±0.54)ng/mL vs(3.37±0.40)ng/mL,(38.95±5.10)ng/mL vs(32.74±4.58)ng/mL],TNF-α明显低于对照组[(1.43±0.37)ng/mL vs(2.22±0.51)ng/mL];两组不良反应总发生率分别为6.67%(4/60)、13.33%(8/60),比较无显著差异;疗程结束后,观察组治愈25例,对照组治愈17例,随访3个月内显示,观察组复发率为8.00%(2/25),明显低于对照组的35.29%(6/17)。结论:在扁平疣患者中使用消疣颗粒、匹多莫德联合聚肌胞皮损内注射效果显著,可有效促进皮损恢复、改善细胞免疫功能,降低复发率,且联合用药并未增加药物不良反应,安全性高,值得应用推广。Objective To study clinical analysis of Xiaoyou Granule,pidotimod combined with intramuscular injection of polyinosinic-polycytidylic acid in treatment of flat wart.Methods 120 patients of flat wart who received therapy from February 2014 to February 2017 in our hospital were selected as research objects,according to random number table,those patients were divided into the observation group(n=60)and the control group(n=60),the control group was treated with 0.1%-dimensional A acid cream,on this basis,while the observation group was treated with Xiaoyou Granule^+pidotimod combined with Polyinosinic-polycytidylic Acid Injection.They were treated with 4 weeks as 1 courses,and 2 courses of treatment were continuously treated.The clinical efficacy,the changes of T lymphocyte subsets(CD3^+,CD4^+,CD4^+/CD8^+),interleukins-6(IL-6),interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α)before and after treatment,and the adverse reaction and recurrence rate of the two groups were compared.Results After treatment,the total effective rate of clinical efficacy in the observation group was 96.67%(58/60),which was significantly higher than that of the control group 78.33%(47/60);after treatment,the CD3^+,CD4^+,CD4^+/CD8^+of the two groups were significantly higher than those before the treatment,the CD3^+,CD4^+,CD4^+/CD8^+in the observation group were significantly higher than that of the control group[(60.71±8.40)%vs(57.39±7.17)%,(40.84±5.31)%vs(36.18±5.06)%,(1.46±0.20)vs(1.27±0.19)];after treatment,the two groups of IL-2 and INF-γwere significantly higher than those before treatment,and TNF-αdecreased significantly,the IL-2 and INF-γin the observation group were significantly higher than that of the control group[(4.29±0.54)ng/mL vs(3.37±0.40)ng/mL,(38.95±5.10)ng/mL vs(32.74±4.58)ng/mL],the TNF-αwas significantly lower than that of the control group[(1.43±0.37)ng/mL vs(2.22±0.51)ng/ml];The total incidence of adverse reactions in the two groups was 6.67%(4/60)and 13.33%(8/60),and there was no significant differe

关 键 词：扁平疣 消疣颗粒 匹多莫德 聚肌胞注射液 免疫功能 细胞因子 

分 类 号：R752.52[医药卫生—皮肤病学与性病学]