ZIF-90二氧化锰纳米片复合材料的制备及用于谷胱甘肽的检测  

Preparation of ZIF-90 Manganese Dioxide Nanosheet Composite and Its Application for Glutathione Detection

作　　者：夏紫薇 靳瑜琴 郑静[1] 张敏[1] 尹学博 XIA Zi-Wei;JIN Yu-Qin;ZHENG Jing;ZHANG Min;YIN Xue-Bo(Institute of Frontier Medical Technology,College of Chemistry and Chemical Engineering,Shanghai University of Engineering Science,Shanghai 201620,China)

机构地区：[1]上海工程技术大学化学化工学院,医药前沿技术研究院,上海201620

出　　处：《分析化学》2023年第5期892-900,共9页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(No.22174077)资助

摘　　要：采用低温溶解氧氧化的方法在金属有机框架材料ZIF-90上原位生长二氧化锰(MnO_(2))纳米片,制备了ZIF-90-MnO_(2)纳米片复合材料。ZIF-90为MnO_(2)纳米片的生长提供了成核位点和支撑,提高了MnO_(2)纳米片的分散性和利用率。基于ZIF-90-MnO_(2)的类氧化酶活性构建了比色传感器,用于谷胱甘肽(GSH)的比色传感检测。在优化的实验条件下,检测GSH的线性范围为1.25~30μmol/L,检出限为0.30μmol/L(3σ),检测过程仅需15 min,并且血清样品中常见共存物不干扰检测。本研究提出的在温和条件下制备ZIF-90-MnO_(2)纳米片复合材料的策略有望拓展MnO_(2)及其类氧化酶活性的应用范围。ZIF-90-MnO_(2)nanosheet composite was prepared by growing MnO_(2)nanosheets on ZIF-90 at 55°C with dissolved oxygen.ZIF-90 provided nucleation sites and support for the growth of MnO_(2)nanosheets and thus improved the dispersion and oxidase activity of MnO_(2)nanosheets.A colorimetric sensor based on the oxidase-like activity of ZIF-90-MnO_(2)was constructed to detect glutathione(GSH)colorimetrically.Under the optimized experimental conditions,the detection limit of GSH was 0.30μmol/L(3σ),the linear range was 1.25-30μmol/L,and the whole detection was completed within 15 min.Coexisting substances in the serum samples did not interfere with the detection.The strategy of preparing ZIF-90-MnO_(2)nanosheet composite under mild conditions was expected to extend the application of MnO_(2)as an oxidase-like enzyme.

关 键 词：二氧化锰 ZIF-90 谷胱甘肽 比色法检测 

分 类 号：TB332[一般工业技术—材料科学与工程] O652[理学—分析化学]