基于氮掺杂钴金属有机框架材料修饰电极电化学传感器灵敏检测盐酸克伦特罗  

Sensitive Detection of Clenbuterol by Electrochemical Sensor Based on N-doped Cobalt Metal Organic Framework Modified Electrode

作　　者：杨启 李恳恳 魏培媛 牛孜莙 王雯雯 刘丽[1] 王松磊[1] YANG Qi;LI Ken-Ken;WEI Pei-Yuan;NIU Zi-Jun;WANG Wen-Wen;LIU Li;WANG Song-Lei(College of Food and Wine,Ningxia University,Yinchuan 750021,China)

机构地区：[1]宁夏大学食品与葡萄酒学院,银川750021

出　　处：《分析化学》2023年第4期559-569,共11页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(No.31660484);宁夏优秀青年科学基金项目(No.2022AAC05022)资助

摘　　要：以1,3,5-均苯三甲酸(H_(3)BTC)作为配体,Co^(2+)和聚乙烯吡咯烷酮(PVP)为中心金属离子和氮源,采用溶剂热法合成了金属有机框架材料N-Co-MOF,采用扫描电子显微镜(SEM)、透射电子显微镜(TEM)、X射线衍射(XRD)、傅里叶红外光谱(FT-IR)和X射线光电子能谱(XPS)技术对材料的形貌和成分进行了表征。将N-Co-MOF修饰在玻碳电极(GCE)表面构建了盐酸克伦特罗(CLB)电化学传感器,循环伏安(CV)表征结果表明,N-Co-MOF可以提供更多的电化学活性位点,能够显著提高电子转移能力,并且对CLB具有良好的电催化氧化活性。将此传感器用于检测CLB,线性范围为0.01~29.5μmol/L,检出限(3σ)为4.6 nmol/L。此传感器具有优异的抗干扰性能、良好的重现性和高稳定性,用于实际肉类样品中CLB的检测,加标回收率为98.5%~102.9%。N-doped cobalt metal organic framework(N-Co-MOF)was synthesized by solvothermal method using trimesic acid as ligand and Co^(2+)and polyvinyl pyrrolidone(PVP)as central metal ions and nitrogen source.The morphology and composition of the materials were characterized by scanning electron microscopy(SEM),transmission electron microscopy(TEM),X-ray diffraction(XRD),Fourier infrared spectroscopy(FT-IR)and X-ray photoelectron spectroscopy(XPS).The electrochemical sensor for detection of clenbuterol(CLB)was constructed on glassy carbon electrode(GCE)modified with N-Co-MOF.The cyclic voltammetry(CV)characterization results showed that the N-Co-MOF could provide more electrochemical active sites and significantly improve the electron transfer ability,and had good electrocatalytic oxidation activity for CLB.The linear range of the sensor for CLB was 0.01-29.5μmol/L,and the detection limit(3σ)was 4.6 nmol/L.The sensor had excellent anti-interference performance,good reproducibility and stability,and had good accuracy in detection of CLB in actual meat samples,with recoveries of 98.5%-102.9%.

关 键 词：电化学传感器 盐酸克伦特罗 聚乙烯吡咯烷酮 金属有机框架 循环伏安法 

分 类 号：O657.1[理学—分析化学] TS251.7[理学—化学]