复方磺胺甲噁唑分散片联合克林霉素和卡泊芬净治疗艾滋病合并肺孢子菌肺炎的效果分析  

Clinical analysis of compound sulfamethoxazole dispersible tablets combined with clindamycin and caspofungin in the treatment of AIDS complicated by pneumocystis pneumonia

作　　者：卫峥[1] 马波[1] 王玲 陈国春[1] Wei Zheng;Ma Bo;Wang Ling;Chen Guochun(Department of Infection,the Third People's Hospital of Changzhou,Changzhou 213000,China)

机构地区：[1]江苏省常州市第三人民医院感染科,213000

出　　处：《临床医学》2022年第12期86-88,共3页Clinical Medicine

摘　　要：目的探讨复方磺胺甲噁唑分散片联合克林霉素和卡泊芬净治疗艾滋病合并肺孢子菌肺炎的效果。方法选取常州市第三人民医院2012年6月至2022年6月收治的60例艾滋病合并肺孢子菌肺炎患者为研究对象。根据随机排列法分为研究组与对照组,每组30例。研究组服用复方磺胺甲噁唑联合克林霉素和卡泊芬净治疗,对照组采取复方磺胺甲噁唑联合克林霉素治疗,用药3周后评价两组治疗总有效率,服药前后测量乳酸脱氢酶(LDH)、白蛋白(ALB)、血氧饱和度(SaO2)、血浆1-3-β-D葡聚糖水平,比较两组用药结果。结果研究组治疗总有效率(93.33%,28/30)高于对照组(73.33%,22/30),差异有统计学意义(χ^(2)=4.320,P=0.038<0.05)。两组用药前血清LDH、ALB水平比较差异未见统计学意义(P>0.05);用药后研究组LDH水平低于对照组,ALB水平高于对照组(P<0.05)。两组用药前SaO2、1-3-β-D葡聚糖水平比较,差异未见统计学意义(P>0.05);用药后研究组SaO2高于对照组,1-3-β-D葡聚糖水平低于对照组(P<0.05)。结论复方磺胺甲噁唑分散片联合克林霉素和卡泊芬净治疗艾滋病合并肺孢子菌肺炎的效果更理想,可以促进症状减轻,提升血氧饱和度。Objective To investigate the efficacy of compound sulfamethoxazole dispersible tablets combined with clindamycin and caspofungin on AIDS complicated with pneumocystis pneumonia.Methods Sixty cases of AIDS patients with pneumocystis pneumonia admitted to Changzhou Third People’s Hospital from June 2012 to June 2022 were selected as the study subjects.According to the random arrangement method,they were divided into the study group and the control group,with 30 cases in each group.The study group was treated with compound sulfamethoxazole combined with clindamycin and caspofungin,while the control group was treated with compound sulfamethoxazole combined with clindamycin.The total effective rate of the two groups was evaluated 3 weeks after administration,and the levels of lactate dehydrogenase(LDH),albumin(ALB),blood oxygen saturation(SaO2),and plasma 1-3-β-D-glucan were measured before and after administration,and the effect of the two groups were compared.Results The total effective rate of the study group(93.33%,28/30)was higher than that of the control group(73.33%,22/30),with significant difference(χ^(2)=4.320,P=0.038<0.05).There was no significant difference in LDH,ALB between the two groups before treatment(P>0.05).The LDH level in the study group was lower than that in the control group,but the ALB level was higher than that in the control group(P<0.05).There was no significant difference in SaO2,plasma 1-3-β-D-glucan before administration in both groups(P>0.05).The level of SaO2in the study group was higher than that in the control group after administration,but the level of 1-3-β-D-glucan was lower than that in the control group(P<0.05).Conclusions The compound sulfamethoxazole dispersible tablets,clindamycin and caspofungin can reduce the clinical symptoms,and improve the blood oxyge staturation of patients with acquired immune deficiency syndrome complicated by pneumocystis pneumonia.

关 键 词：艾滋病 肺孢子菌肺炎 复方磺胺甲噁唑分散片 克林霉素 卡泊芬净 

分 类 号：R512.91[医药卫生—内科学] R563.1[医药卫生—临床医学]