线圈型磁通量传感器多路复用结构优化研究  

Research on multiplexing structure optimization of coil-type magnetic flux sensor

作　　者：李唐安 郑楚君 孙清雯 崔大祥 王侃[1,2] Li Tang'an;Zheng Chujun;Sun Qingwen;Cui Daxiang;Wang Kan(School of Electronic Information and Electrical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China;Key Laboratory of Thin Film and Microfabrication Technology(Ministry of Education),Shanghai Jiao Tong University,Shanghai 200240,China)

机构地区：[1]上海交通大学电子信息与电气工程学院,上海200240 [2]上海交通大学中国科学院薄膜与微细加工技术重点实验室,上海200240

出　　处：《电子测量与仪器学报》2023年第11期14-23,共10页Journal of Electronic Measurement and Instrumentation

基　　金：国家自然科学基金委员会国际合作与交流项目(82020108017);中国国家自然科学基金(32171373,82272821,81903169)项目资助

摘　　要：线圈型磁通量检测技术已大量应用于临床诊断应用中,但相邻磁检测信号容易出现信号混叠现象。现有研究大多采用算法处理和样本空间隔离的方式避免信号的相互干扰,限制了该技术在体外快速诊断领域中的发展。针对上述问题,本研究采用数学物理建模结合有限元仿真的形式分析了线圈型磁通量传感器的结构,并进行了传感器结构优化。最终实验结果表明,优化后的传感器能有效地区分间距为4 mm的相邻磁信号源。针对临床样本胃泌素17的免疫层析定量检测中,检测范围达到11 pg/mL~110 ng/mL。上述结果证实了优化后传感器结构具备多路同步复用检测能力。Coil-type magnetic flux detection technology has been widely used in clinical diagnosis applications.However,adjacent magnetic samples’detection signals are prone to aliasing.Most of the existing researches used algorithm processing and sample space isolation to avoid the mutual interference of signals,which limits the development of this technology in the field of point-of-care testing.In view of the above problems,this study uses mathematical physical modeling combined with finite element simulation to analyze the structure of the coil-type magnetic flux sensor,and optimizes the sensor structure.The final experimental results show that the optimized sensor can effectively distinguish the adjacent magnetic signal sources with a distance of 4 mm.In the immunochromatographic quantitative detection of gastrin-17 in clinical samples,the detection range reached 11 pg/mL~110 ng/mL.The above result confirm that the optimized sensor structure has the capability of multiplex synchronous multiplexing detection.

关 键 词：磁通量 定量检测 POCT 有限元仿真分析 多路同步检测 

分 类 号：TN05[电子电信—物理电子学]