1992—2020年中国人群HBsAg阳性率变化的Meta分析  

Meta-analysis of changes in HBsAg positive rate in Chinese population from 1992 to 2020

作　　者：陈欣亦 杨光军 惠宇 黄小玲[1] CHEN Xin-yi;YANG Guang-jun;HUI Yu;HUANG Xiao-ling(School of Management,Hainan Medical University,Haikou,Hainan 570100,China)

机构地区：[1]海南医学院管理学院,海南海口570100

出　　处：《中国公共卫生管理》2022年第4期522-525,536,共5页Chinese Journal of Public Health Management

基　　金：海南省哲学社会科学规划课题[HNSK(YB)17-49];海南省自然科学基金项目(20168272,821RC574)

摘　　要：目的通过分析1992—2020年乙型肝炎病毒表面抗原(Hepatitis B surface antigen,HBsAg)携带率变化趋势,评价我国乙型肝炎免疫规划策略的实施效果,为我国制定不同地区的乙型肝炎防控措施提供科学依据。方法通过检索中国知网(CNKI)、万方、维普和Pubmed等数据库,收集1992—2020年有关HBsAg携带率的文献,采用STATA SE 12.0软件对符合纳入和排除标准的文献进行Meta分析。结果共纳入73篇文献、792411名研究对象。2005—2018年我国东中西部地区乙肝病毒携带率分别为0.073、0.060、0.064。2005—2018年我国南北方乙型肝炎病毒携带率分别为0.074、0.042。结论自1992年乙型肝炎疫苗普及以来,我国乙型肝炎病毒携带率总体呈逐年下降趋势,现属中度流行区。应继续贯彻落实乙型肝炎防疫政策。我国东部地区乙型肝炎病毒携带率高于中部和西部地区,南方乙型肝炎病毒携带率高于北方。因此,对不同的省份应实施有针对性的控制措施。Objective By analyzing the change trend of HBsAg carrier rate from 1992 to 2020,to evaluate the implement effect of China’s hepatitis B vaccine immunization program strategy,and to provide scientific basis for the formulation of hepatitis B prevention and control measures in different regions in China.Methods By searching databases,such as China National Knowledge Infrastructure(CNKI),Wanfang,VIP and Pubmed,the literature on HBsAg carrier rate from1992 to 2020 was collected.Meta analysis was done on the literature conforming to the criteria through STATA/SE 12.0software.Results A total of 73 articles with 792411 subjects were included.HBV carrier rates in eastern,central and western China from 2005 to 2018 were 0.073,0.060 and 0.064.The carrier rates of HBV in the southern and northern regions in China from 2005 to 2018 were 0.074 and 0.042.Conclusion Since the popularization of hepatitis B vaccine in 1992,the carrier rate of HBV in China shows a downward trend year by year.It is now a moderately endemic area.It is necessary to continuously implement hepatitis B epidemic prevention policy.According to the regional distribution analysis,the carrier rate of HBV in central,western and southern regions in China is higher than the northern region.So different provinces should implement targeted control measures.

关 键 词：META分析 HBSAG阳性率 乙型肝炎 中国 

分 类 号：R512.62[医药卫生—内科学]