北京市昌平区2型糖尿病患者骨质疏松现况及其影响因素研究  

Status and influencing factors of osteoporosis in patients with type 2 diabetes mellitus in Changping District,Beijing

作　　者：高坦 刘梅娟[1] 邓微[1] 陈佳[1] GAO Tan;LIU Mei⁃juan;DENG Wei;CHEN Jia(Beijing Jishuitan Hospital,Beijing 100096,China)

机构地区：[1]北京积水潭医院,北京100096

出　　处：《华南预防医学》2022年第8期934-937,942,共5页South China Journal of Preventive Medicine

摘　　要：目的探讨北京市昌平区2型糖尿病(T2DM)患者骨质疏松现况及其影响因素。方法2020年10月在北京市昌平区16个街镇社区服务中心中招募T2DM患者作为调查对象,对符合研究条件的T2DM患者进行资料收集、体格检查、血生化指标检测及骨密度检测。采用描述性分析方法对T2DM患者骨质疏松发生情况进行分析,并采用单、多因素分析方法对T2DM患者骨质疏松发生影响因素进行分析。结果本研究招募符合研究条件且数据有效的T2DM患者2126例,年龄22~76岁,病程以1~9年为主,占68.53%。2126例T2DM患者骨质疏松发生率为10.11%。多因素Logistic回归分析结果显示,年龄(OR=2.512)、病程(OR=1.956)、BMI(OR=0.399)、吸烟(OR=2.895)、体育锻炼(OR=0.459)、血糖监测情况(OR=2.533)、糖化血红蛋白(HbA1c)水平(OR=3.517)、甲状旁腺激素水平(PTH)(OR=2.777)、碱性磷酸酶(ALP)水平(OR=3.452)、25羟维生素D[25(OH)D]水平(OR=1.982)均为T2DM病例合并骨质疏松的影响因素。结论北京市昌平区T2DM患者骨质疏松发生风险较高,其影响因素包括年龄、病程、BMI、吸烟、体育锻炼情况、血糖监测情况、HbA1c、PTH、ALP、25(OH)D水平,据此完善临床防治体系,有利于降低T2DM患者骨质疏松发生风险。Objective To investigate the status and influencing factors of osteoporosis in patients with type 2 diabetes mellitus(T2DM)in Changping District,Beijing.Methods In October 2020,T2DM patients were recruited as survey subjects in 16 community service centers in Changping District,Beijing.Data collection,physical examination,blood biochemical index detection,and bone mineral density detection were performed on T2DM patients who met the research conditions.The descriptive analysis method was used to analyze the incidence of osteoporosis in T2DM patients,and univariate and multivariate analysis methods were used to analyze the influencing factors of osteoporosis in T2DM patients.Results A total of 2126 T2DM patients with valid data were recruited in this study,aged 22-76 years old,and the course of disease was mainly 1-9 years,accounting for 68.53%.The incidence of osteoporosis in 2126 T2DM patients was10.11%.The multivariate Logistic regression model showed that age(OR=2.512),course of disease(OR=1.956),body mass index(BMI)(OR=0.399),smoking(OR=2.895),physical exercise(OR=0.459),blood glucose monitoring(OR=2.533),glycosylated hemoglobin(HbA1c)(OR=3.517),parathyroid hormone(PTH)(OR=2.777),alkaline phosphatase(ALP)(OR=3.452),25-hydroxyvitamin D[25(OH)D](OR=1.982)were influencing factors of osteoporosis in T2DM patients.Conclusion T2DM patients in Changping District of Beijing have a higher risk of osteoporosis,and the influencing factors include age,course of disease,BMI,smoking,physical exercise,blood glucose monitoring,HbA1c,PTH,ALP,and 25(OH)D levels.Improving the clinical prevention and treatment system will help reduce the risk of osteoporosis in T2DM patients.

关 键 词：骨质疏松 2型糖尿病 骨密度 影响因素 

分 类 号：R587.2[医药卫生—内分泌] R580[医药卫生—内科学]