Clinical study of acupuncture plus Dang Gui Bu Xue Qu Feng Tang for benign essential blepharospasm  

针刺结合当归补血祛风汤治疗特发性眼睑痉挛的临床研究

作　　者：ZOU Yuelan KONG Xiehe GUO Xiaocong WANG Xuejun LI Xiaoying HAN Rong ZHANG Xiaopeng YANG Guang YANG Yanting MA Xiaopeng 邹月兰;孔谐和;郭潇聪;王雪君;李晓莹;韩榕;张小芃;杨光;杨延婷;马晓芃(Department of Ophthalmology,Shanghai Eye Diseases Prevention&Treatment Center,Shanghai 200040,China;Shanghai Research Institute of Acupuncture and Meridian,Shanghai 200030,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai Qigong Research Institute,Shanghai 200030,China)

机构地区：[1]Department of Ophthalmology,Shanghai Eye Diseases Prevention&Treatment Center,Shanghai 200040,China [2]Shanghai Research Institute of Acupuncture and Meridian,Shanghai 200030,China [3]Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China [4]Shanghai Qigong Research Institute,Shanghai 200030,China

出　　处：《Journal of Acupuncture and Tuina Science》2022年第1期79-86,共8页针灸推拿医学（英文版）

基　　金：上海市卫生和计划生育委员会项目,No.2018LP027;国家自然科学基金青年项目,No.81904302

摘　　要：Objective:To evaluate the therapeutic efficacy of acupuncture plus Dang Gui Bu Xue Qu Feng Tang for benign essential blepharospasm(BEB).Methods:A prospective randomized controlled trial was performed.A total of 105 participants were randomized 1:1:1 into an acupuncture group,a herbal medicine group and an acupuncture plus herbal medicine group.Participants in the acupuncture group received manual acupuncture treatment,twice a week.Participants in the herbal medicine group received Dang Gui Bu Xue Qu Feng Tang,oral administration,once a day.Participants in the acupuncture plus herbal medicine group received both treatments.The therapeutic effects of the three groups were evaluated after four weeks of treatment.The primary outcome was the Jankovic rating scale(JRS)score,and the secondary outcome was the blepharospasm disability index(BSDI)score.Results:After four weeks of treatment,the JRS total scores significantly decreased in all three groups versus baseline(P<0.05).A greater reduction in the JRS total score was reported in participants in the acupuncture plus herbal medicine group(P<0.05),but there was no significant difference between the acupuncture group and the herbal medicine group(P>0.05).The acupuncture plus herbal medicine group had a greater decrease in the JRS severity score than the herbal medicine group(P<0.05).The reduction in the JRS frequency score was not significantly different among the three groups(P>0.05).The BSDI scores significantly decreased in all three groups versus baseline(P<0.05),but the reduction in the BSDI score was insignificantly different among the three groups(P>0.05).Conclusion:It is effective in the treatment of BEB either to use acupuncture and Dang Gui Bu Xue Qu Feng Tang alone or in combination.The combination therapy shows a more significant effect than either of the treatment alone.目的:观察针刺结合当归补血祛风汤对特发性眼睑痉挛(BEB)的影响.方法:采用前瞻性、随机试验设计,将105例BEB受试者按1:1:1随机分为针刺组、中药组和针药结合组.针刺组采用单纯针刺治疗,2次/周.中药组采用当归补血祛风汤口服,每日1剂.针药结合组采用针刺联合中药治疗.三组均治疗4周后观察疗效.主要疗效指标为扬科维奇评分(JRS),次要疗效指标为眼睑痉挛残疾指数(BSDI).结果:治疗4周后,三组的JRS总分均较治疗前显著下降(P<0.05),针药结合组较针刺组和中药组下降幅度大(P<0.05),而针刺组和中药组比较差异无统计学意义(P>0.05).在JRS严重程度评分的降低幅度上,针药结合组大于中药组(P<0.05).在JRS频率评分的降低幅度上,三组比较差异无统计学意义(P>0.05).治疗后,三组BSDI评分均较治疗前显著下降(P<0.05),三组下降幅度差异无统计学意义(P>0.05).结论:针刺和当归补血祛风汤单独或联合使用治疗BEB均有一定临床疗效,联合使用的疗效优于单独使用.

关 键 词：Acupuncture Therapy Acupuncture Medication Combined Chinese Herbal Drugs Dang Gui Bu Xue Qu Feng Tang BLEPHAROSPASM Clinical Trial 

分 类 号：R246.8[医药卫生—针灸推拿学]