复合喷剂敷料治疗头皮脂溢性皮炎的有效性及安全性研究  

The efficacy and safety of the compound yufa anti-dandruff shampoo for the treatment of scalp seborrheic dermatitis

作　　者：陈曦[1] 殷玥 王幼学 金星姬[1] 魏爱华[1] CHEN Xi;YIN Yue;WANG You-xue(Department of Dermatology,Beijing Tongren Hospital,CMU,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院皮肤科,北京100730

出　　处：《实用皮肤病学杂志》2023年第5期279-283,共5页Journal of Practical Dermatology

基　　金：国家自然科学基金青年基金项目(82203951)

摘　　要：目的研究以抗菌肽为主成分的复合喷剂敷料域发去屑洗剂治疗头皮脂溢性皮炎的效果和安全性。方法入组30例轻度至中度脂溢性皮炎患者,入组后第1~7天,每天使用试验产品治疗1次;在第8~28天,每2天使用试验产品治疗1次,分别在治疗的第0天(接受治疗前)、第14天、第28天随访,拍摄临床及皮肤镜照片,通过黏着性头屑10级评分(ASFS)、脂溢性皮炎头皮皮损临床量表、瘙痒评分量表分别评估患者头屑、红斑、丘疹及瘙痒的严重程度,同时要求患者完成头皮自觉症状评分,并填写皮肤病生活质量指数评分(DLQI)问卷。询问并记录研究过程中患者所有不良反应。结果受试者在使用域发去屑洗剂后,头屑明显减少,平均ASFS评分由(11.00±8.094)分降至(2.57±2.22)分(P<0.001),有效率达90%;红斑、丘疹缓解,皮损量表评分由(1.67±0.61)分降至(0.57±0.68)分(P<0.001),有效率达76.7%;瘙痒症状缓解,量表评分由(1.83±0.46)分降至(0.73±0.69)分(P<0.001),有效率达76.7%;患者头皮刺痛、烧灼、油腻的自觉症状亦有不同程度改善,且DLQI显著改善,由(10.47±4.87)分降至(3.53±3.50)分(P<0.05);仅3例患者入眼有轻微刺痛感,可自行好转。结论域发去屑洗剂可有效改善脂溢性皮炎患者头屑、红斑、丘疹及瘙痒症状,安全性良好。Objective To study the efficacy and safety of Yufa Anti-dandruff Shampoo,with antimicrobial peptides as the main ingredient,in the treatment of scalp seborrheic dermatitis.Methods Thirty patients with mild to moderate seborrheic dermatitis were enrolled and treated with the product once a day from D1 to D7,and every 2 days from D8 to D28.Follow-up was conducted on D0,D14 and D28.Clinical and dermoscopic photos were taken.The severity of dandruff was evaluated using the Adherent Scalp Flaking Score(ASFS),the skin lesion score of seborrheic dermatitis,and the dynamic pruritus score for the symptom of rash and itching,respectively.The patients also provided subjective scores of conscious symptoms and completed dermatology life quality index(DLQI).All adverse reactions during the study were documented.Results Dandruff was significantly reduced after using the shampoo.The average ASFS score decreased from 11.00±8.094 to 2.57±2.22(P<0.001),with an effective rate of 90%.Erythema and papules were relieved,and the score of lesion scale decreased from 1.67±0.61 to 0.57±0.68(P<0.001),with an effective rate of 76.7%.Pruritus symptoms were relieved,with the scale score decreasing from 1.83±0.46 to 0.73±0.69(P<0.001),with an effective rate of 76.7%.In addition,the subjective symptoms of scalp tingling,burning and greasy were also improved to varying degrees,and the DLQI score was significantly improved from 10.47±4.87 to 3.53±3.50(P<0.05).The product exhibited good safety,with only 3 subjects experiencing slight irritation in the eyes,which resolved on their own.Conclusion Yufa Anti-dandruff Shampoo improves the symptoms of dandruff,erythema lesions and itching in patients with seborrheic dermatitis,and demonstrates good safety.

关 键 词：皮炎 脂溢性 头屑 抗菌肽 域发去屑洗剂 

分 类 号：R758.732[医药卫生—皮肤病学与性病学]