细胞因子在类风湿关节炎的研究进展  

Research Progress of Cytokines in Rheumatoid Arthritis

作　　者：廖磊 洪学志 陈晓欢 刘雷 王亚慧 莫汉有[1] LIAO Lei;HONG Xue-zhi;CEHN Xiao-huan;LIU Lei;WANG Ya-hui;MO Han-you(Department of Rheumatology,Affiliated Hospital of Guilin Medical College,Guilin Guangxi 541000)

机构地区：[1]桂林医学院附属医院风湿免疫科,广西桂林541000

出　　处：《世界最新医学信息文摘》2021年第6期75-77,共3页World Latest Medicine Information Electronic Version

基　　金：国家自然科学基金(81360462,81760298)。

摘　　要：类风湿关节炎(Rheumatoid arthitis,RA)是一种病因未明的慢性、以炎性滑膜炎为主的自身免疫性疾病.细胞因子在RA的发病过程中起关键作用,其中促炎细胞因子如:肿瘤坏死因子-α(TNF-α)、白细胞介素1(IL-1)、IL-6、IL-17、IL-33等通过促进炎症反应和诱导软骨降解发挥作用,而抗炎细胞因子IL-4、IL-10、IL-13等可以减轻炎症反应.文章以促炎细胞因子与抗炎细胞因子的角度综述细胞因子在类风湿关节炎的作用.Rheumatoid Arthitis(RA)i s a chronic,largely inflammatory autoimmune disease of unknown eti ology.Cytokines play a key role in the pathogenesis of RA.Pro-inflam matory cytokines such as tumor necrosis factor(TNF-),interleukin 1(IL-1),IL-6,IL-17 and IL-33 play a role by promoting inflammation and inducing cartilage degradation,while anti-inflammatory cytokines such as IL-4,IL-10 and IL-13 can reduce inflammation.This article reviews the role of cytokines in rheumatoid arthritis from the perspective of proinflammatory cytokines and anti-inflammatory cytokines.

关 键 词：类风湿关节炎 促炎细胞因子 抗炎细胞因子 

分 类 号：R593.22[医药卫生—内科学]