Risk factors and prediction of macrosomia in a cohort study  

作　　者：Jie Xi Zhi-Ping Zhang Li-Xin Yang Yan Chen Ya-Jing Mao Qiu-Feng Liang Miao Xiong 

机构地区：[1]Obstetrics,Jiading District Maternal and Child Health Hospital,Shanghai 201821 [2]Obstetrics,Pudong New District Maternal and Child Health Hospital,Shanghai 201206 [3]East Hospital of Shanghai Sixth People's Hospital,Shanghai 201306

出　　处：《Journal of Hainan Medical University》2019年第19期62-67,共6页海南医学院学报（英文版）

基　　金：Key Medical Speciality (Obstetrics) of Jiading District, Shanghai (JDYXZDZK-8)

摘　　要：Objective: To investigate the risk factors of macrosomia and to predict the risk of macrosomia so as to reduce the incidence of macrosomia. Methods: A total of 2063 pregnant women who met the inclusion criteria were selected as the subjects from February 2016 to April 2017 in Jiading District Maternal and Child Health Hospital of Shanghai and Pudong New Area Maternal and Child Health Hospital. According to the birth weight of the neonates, the neonates were divided into the macrosomia group (neonatal weight > 4000 g, n=125) and the normal infant group (2500 g < neonatal weight < 4000 g, n=1938).The general data of age, number of pregnant women, BMI before pregnancy, gestational diabetes mellitus, glucose tolerance, weight gain during pregnancy, birth weight and gestational week were compared between the two groups. Multivariate logistic regression was used to analyze the risk factors of macrosomia. Results: ①There were significant differences in BMI, glucose tolerance, fasting blood sugar, weight gain in the second trimester, weight gain in the third trimester, birth weight and gestational week between the two groups (P<0.05). ②Single factor analysis showed that pre-pregnancy BMI, gestational week at first diagnosis, fasting blood glucose tolerance, weight gain in the second trimester, weight gain in the third trimester, gestational week and birth weight were the influencing factors of macrosomia (P<0.05). ③Multi-factor analysis showed that gestational weeks, gestational diabetes, fasting glucose tolerance and weight growth in the second trimester were the main factors affecting the production of macrosomia, among which gestational diabetes was the protective factor, while gestational weeks, fasting glucose tolerance and weight growth in the second trimester were the risk factors. Conclusion: The high risk factors for macrosomia are gestational weeks, glucose tolerance, fasting blood sugar and weight gain in the second trimester of pregnancy.We should strengthen regular obstetric examination, health care du

关 键 词：MACROSOMIA NEONATES Risk factors Logistic regression analysis 

分 类 号：R58[医药卫生—内分泌]