Ulcer protective effect of Byrsocarpus coccineus leaf extract in different experimental animal models  

作　　者：Akuodor Godwin Christian Udia Pius Monday Akpan Joseph Linus Ezeokpo Basil Chukwuma Okezie Ogwuegbu Alozie Ghasi Samuel Ikenna Nwadike Kenneth Ikechukwu 

机构地区：[1]Department of Pharmacology and Therapeutics,Faculty of Clinical Medicine,Ebonyi State University,Abakaliki,Nigeria [2]Department of Pharmacology,College of Medical Sciences,University of Calabar,Cross River State,Nigeria [3]Department of Chemical Pathology,Federal Teaching Hospital,Abakaliki,Nigeria [4]Department of Pharmacology and Therapeutics,College of Medicine,University of Nigeria,Enugu Campus,Nigeria

出　　处：《Journal of Coastal Life Medicine》2015年第9期728-732,共5页海岸生命医学杂志（英文版）

摘　　要：Objective:To evaluate the antiulcer activity of ethanolic leaf extract of Byrsocarpus coccineus,a plant used in herbal medicine for the management of various diseases in Nigeria.Methods:Ethanol-,acetylsalicylic acid-,histamine-and water immersion stress-induced gastric ulcers in rats were used to investigate the antiulcer activity of the leaf extract.Acute toxicity studies were also carried out.Results:The ethanolic leaf extract significantly(P<0.05)reduced the ulcer index in all assays used with the maximal antiulcer activity recorded at 400 mg/kg.The LD_(50)values obtained were greater than 5000 mg/kg in rats.Conclusions:The implication of this finding is that Byrsocarpus coccineus ethanolic leaf extract possesses potent antiulcer activity and the leaf of this plant can serve as a potential source of safe and affordable antiulcer agents.

关 键 词：Byrsocarpus coccineus LEAVES Ethanol extract ANTIULCER RATS 

分 类 号：R28[医药卫生—中药学]