小而密低密度脂蛋白胆固醇在诊断心血管疾病及相关性的探究  

作　　者：吴寿军 毛丽萍[1] 陈雷阳 刘艳梅[1] 

机构地区：[1]浙江省浦江县人民医院,322200

出　　处：《浙江临床医学》2019年第6期844-846,共3页Zhejiang Clinical Medical Journal

摘　　要：目的 探究小而密低密度脂蛋白胆固醇(sdLDL-C)水平结合甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)和脂蛋白a(Lpa)指标检测与心血管疾病发病及指标间的相关性.方法 选择2017年1月至12月在本院心内科住院的冠心病等心血管病患者108例作为观察组,选择同期在本院健康体检中心的健康体检者114例作为对照组.采用全自动生化分析仪检测sdLDL-C、TG、HDL-C、LDL-C、ApoA1、ApoB、Lpa的水平.采用SPSS?19.0统计软件进行相关数据分析.结果? 观察组sdLDL-C、LDL-C、TG、ApoB、Lpa水平明显高于健康对照组(P<0.01),而HDL-C、ApoA1水平则均明显低于健康对照组(P<0.01).sdLDL-C水平与LDL-C、TG、ApoB、Lpa呈正相关,与LDL-C、ApoB的相关系数较大,均>0.800,与TG的相关系数为0.638,与Lpa的相关系数达到0.495;与HDL-C呈显著的负相关,但与ApoA1无显著的相关性.sdLDL-C和sdLDL-C/LDL-C比率可作为冠心病等心血管病发病的独立危险因素.结论 血清sdLDL-C水平与其他血脂指标多存在关联,血脂常用项目联合sdLDL-C、sdLDL/LDL-C比率对于冠心病等心血管疾病的早期预测可能具有较高的临床价值.Objective To explore the combined detection of small and dense low-density lipoprotein cholesterol(sdLDL-C)with triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoprotein A1(ApoA1),apolipoprotein B(ApoB),lipoprotein a(Lpa)and the association between the indicators and cardiovascular diseases.Methods 108 cardiovascular disease patients recruited as patient group,were selected from January to December 2017 in Cardiology department.114 healthy cases served as control group.The levels of sdLDL-C,TG,HDL-C,LDL-C,ApoA1,ApoB and Lpa were detected by automatic biochemical analyzer.Data was analyzed by SPSS 19.0 software.Results The levels of serum sdLDL-C,LDL-C,TG,ApoB and Lpa in the patients were significantly higher than those in the healthy control group(P<0.01),while the levels of HDL-C and ApoA1 were significantly lower than those in the healthy control group,and the difference was statistically significant(P<0.01).The level of sdLDL-C was positively correlated with LDL-C,TG,ApoB and Lpa.The correlation coefficient with LDL-C and ApoB was larger than 0.800.The correlation coefficient with TG was 0.638 and the correlation coefficient of Lpa reached 0.495;there was a significant negative correlation with HDL-C,but no significant correlation with ApoA1.sdLDL-C and sdLDL-C/LDL-C were independent risk factors for cardiovascular diseases such as coronary heart disease.Conclusion The level of serum sdLDL-C is mostly associated with other indicators.sdLDL-C and sdLDL/LDL-C combined to the commonly indicators may be of high clinical value for the early prediction of cardiovascular diseases,such as coronary heart disease.

关 键 词：小而密低密度脂蛋白胆固醇 心血管疾病 联合诊断 

分 类 号：R5[医药卫生—内科学]