丹参多酚酸盐治疗冠心病的疗效观察  

Observation on Efficacy of Salvianolates in the Treatment of Coronary Heart Disease

作　　者：张志亮[1] Zhang Zhi-liang(Department of Pharmacy,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan 453100,China)

机构地区：[1]新乡医学院第一附属医院药学部,河南新乡453100

出　　处：《中国合理用药探索》2019年第2期105-108,共4页Chinese Journal of Rational Drug Use

摘　　要：目的:研究丹参多酚酸盐治疗冠心病的疗效及对患者心肌酶谱、同型半胱氨酸(Hcy)、转化生长因子(TGF)-β_1、B型脑钠肽(BNP)、γ干扰素(IFN-γ)水平的影响。方法:选取2016年2月—2018年2月我院收治的94例冠心病患者为研究对象,按照随机数字表法分成干预组和对照组,各47例。对照组予以氯吡格雷(入院当天予以300 mg,次日开始减至75 mg,qd)治疗,干预组在对照组基础上予以丹参多酚酸盐(取200 mg加入200 mL 0.9%氯化钠注射液中,静脉输注,qd)治疗。比较两组临床疗效,治疗前后心肌酶谱、Hcy、TGF-β_1、BNP、IFN-γ水平,以及不良反应。结果:干预组总有效率明显高于对照组,差异有统计学意义(P <0.05);治疗后干预组肌酸激酶同工酶(CK-MB)、肌钙蛋白(cTnI)水平明显高于对照组,差异有统计学意义(P <0.05);治疗后干预组Hcy、BNP、IFN-γ水平明显低于对照组,TGF-β_1水平明显高于对照组,差异有统计学意义(P <0.05);两组恶心、腹胀、皮疹、气促发生率比较,差异无统计学意义(P> 0.05)。结论:丹参多酚酸盐治疗冠心病的疗效显著,有利于改善患者心肌酶谱,降低Hcy、BNP、IFN-γ水平,提高TGF-β_1水平,且安全性高,值得临床推广应用。Objective:To study the efficacy of salvianolates in the treatment of coronary heart disease and its effect on myocardial zymogram,homocysteine(Hcy),transforming growth factor(TGF)-β1,B-type natriuretic peptide(BNP)andγ-interferon(IFN-γ)levels.Methods:94 patients with coronary heart disease admitted to our hospital from February 2016 to February 2018 were selected as subjects investigated and randomly divided into an intervention group and a control group,47 cases each.The patients in the control group were treated with clopidogrel(300 mg on the day of admission,reduced to 75 mg on the next day,qd),and the patients in the intervention group were treated with salvianolates(200 mg drug was added to 200 mL 0.9%sodium chloride injection,intravenous infusion,qd).The clinical efficacy,myocardial zymogram,Hcy,TGF-β1,BNP and IFN-γlevels before and after treatment and adverse reactions were compared between the two groups.Results:The total effective rate in the intervention group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of creatinine kinase isoenzyme(CK-MB)and troponin(cTnI)in the intervention group were significantly higher than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of Hcy,BNP and IFN-γin the intervention group were significantly lower than those in the control group,and the level of TGF-β1 was significantly higher than that in the control group,with statistically significant differences(P<0.05).There were no statistically significant differences in the incidences of nausea,bloating,rash and breath shortness between the two groups(P>0.05).Conclusion:Salvianolates have significant efficacy in the treatment coronary heart disease,and help to improve myocardial zymogram,reduce Hcy,BNP and IFN-γlevels and increase TGF-β1 level,which have high safety,and are worthy of clinical application.

关 键 词：冠心病 丹参多酚酸盐 心肌酶谱 同型半胱氨酸 转化生长因子-Β1 

分 类 号：R541.4[医药卫生—心血管疾病]