Bidirectional solid fermentation using Trametes robiniophila Murr. For enhancing efficacy and reducing toxicity of rhubarb (Rheum palmatum L.)  

作　　者：Yancong Zhang Li Zhou Weiwei Ma Xiaosa Shi Hongmei Zhang Xinyuan Shi 

机构地区：[1]School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100102,China

出　　处：《Journal of Traditional Chinese Medical Sciences》2017年第3期306-313,共8页中医科学杂志（英文）

摘　　要：Objective:To investigate the potential of bidirectional solid fermentation of rhubarb (Rheum palmatum L.) for reducing its toxicity and enhancing its medicinal efficacy.Methods:The fungus Trametes robiniophila Murr.was inoculated into rhubarb.The chemical ingredients as well as antioxidant,antibacterial,and anticancer activities of fermented and unfermented rhubarb extracts were then determined.Results:After fermentation,levels of anthraquinone glycosides (purgative ingredients) decreased significantly,while the level of anthraquinone aglycone increased.The level of gallic acid was also reduced after fermentation.Ethanol extract of rhubarb (0.8 mg/mL) exhibited DPPH-scavenging activity of 7.6% ± 0.8% while the blank control (0.8 mg/mL rhubarb)showed 31.3% ± 2.0% activity.Antibacterial activities in fermented samples were found to be enhanced compared with unfermented samples and anticancer activity was evident at concentrations of 2000 and 5000 μg/mL.Conclusion:Bidirectional solid fermentation appears to be an effective processing method that can be used to improve the efficacy and reduce the toxicity of rhubarb.

关 键 词：RHUBARB TRAMETES robiniophila Murr. BIDIRECTIONAL solid FERMENTATION ANTHRAQUINONES Cancer inhibition 

分 类 号：R284.1[医药卫生—中药学]