A prediction of in vivo mechanical stresses in blood vessels using thermal expansion method and its application to hypertension and vascular stenosis  

作　　者：Shaoxiong Yang Lucy T.Zhang Cheng Hua Yunqiao Liu Jingdong Tang Xiaobo Gong Zonglai Jiang 

机构地区：[1]Shaoxiong Yan91·Lucy T.Zhan92,3·Cheng Hua4·Yunqiao Liul·Jingdong Tan95·Xiaobo Gon91,6.Zonglai Jian971Key Laboratory of Hydrodynamics(Ministry of Education),Department of Engineering Mechanics,School of NavalArchitecture,Ocean and Civil Engineering,Shanghai JiaoTong University,Shanghai200240,China [2]Department of Mechanical,Aerospace and NuclearEngineering,Rensselaer Polytechnic Institute,Troy,NY12180.USA [3]School of Mechanical Engineering,Tianjin University ofScience and Technology,Tianjin300222,China [4]Department of Aeronautics and Astronautics,FudanUniversity,Shanghai200433,China [5]Vascular Surgery Department,Shanghai Pudong Hospital,Fudan Affiliated Pudong Medical Center,Shanghai200120,China [6]Collaborative Innovation Center for Advanced Ship and DeepSea Exploration,School of Naval Architecture,Ocean andCivil Engineering,Shanghai Jiao Tong University,Shanghai200240,China [7]Institute of Mechanobiology and Biomedical Engineering,School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Acta Mechanica Sinica》2018年第6期1156-1166,共11页力学学报（英文版）

基　　金：The authors would like to thank Prof.Shu Takagi and Prof.Huaxiong Huang for their instructive comments.The authors would also like to acknowledge Jianda Yang for assisting with FEM simulations.This work was supported by the National Natural Science Foundation of China(Grants 11372191,11232010,11650(Grant 91111138);the National Institute of Health(Grant 2R01DC005642-10A1).

摘　　要：Mechanical stimuli play critical roles in cardiovascular diseases,in which in vivo stresses in blood vessels present a great challenge to predict.Based on the structural-thermal coupled finite element method,we propose a thermal expansion method to estimate stresses in multi-layer blood vessels under healthy and pathological conditions.The proposed method provides a relatively simple and convenient means to predict reliable in vivo mechanical stresses with accurate residual stress.The method is first verified with the opening-up process and the pressure-radius responses for single and multi-layer vessel models.It is then applied to study the stress variation in a human carotid artery at different hypertension stages and in a plaque of vascular stenosis.Our results show that specific or optimal residual stresses exist for different blood pressures,which helps form a homogeneous stress distribution across vessel walls.High elastic shear stress is identified on the shoulder of the plaque,which contributes to the tearing effect in plaque rupture.The present study indicates that the proposed numerical method is a capable and efficient in vivo stress evaluation of patient-specific blood vessels for clinical purposes.

关 键 词：CARDIOVASCULAR disease In VIVO stress MULTI-LAYER VESSEL structure HYPERTENSION Stenosed VESSEL 

分 类 号：R5[医药卫生—内科学]