Antimicrobial resistance pattern in ventilator-associated pneumonia in an intensive care unit of Babol, northern Iran  

作　　者：Mahmoud Sadeghi-Haddad-Zavareh Hadi Ahmadi Jouybari Mostafa Javanian Mehran Shokri Masomeh Bayani Mohammad Reza Hasanjani Roushan Arefeh Babazadeh Soheil Ebrahimpour Parviz Amri Maleh 

机构地区：[1]Infectious Diseases and Tropical Medicine Research Center,Health Research Institute,Babol University of Medical Sciences,Babol,I.R.Iran [2]Department of Anesthesiology,School of Medicine,Babol University of Medical Sciences,Babol,I.R.Iran

出　　处：《Journal of Acute Disease》2018年第2期74-77,共4页急性病杂志（英文版）

摘　　要：Objective:To investigate antibiotic resistance pattern of ventilator-assiated pneumonia (VAP) generating microorganisms,and quantitative culture and determining antibiotic sensitivity.Methods:This cross sectional study was performed on 50 patients suffering from VAP in intensive care unit of Ayatollah Rouhani Hospital,Babol,Iran during 2014-2015.VAP was probable for them based on clinical signs and the criteria of Clinical Pulmonary Infection Score standards.Lower respiratory samples were given under bronchoalveolar lavage and quantitative culture was done on them.Afterwards by microdilution method,minimal inhibitory concentration based on respective microorganisms,considering clinical pulmonary infection score were determined.Results:From 50 investigated samples in this study,the most common microorganisms were Acinetobacter baumannii (A.baumannii) (70%) then Pseudomonas aeruginosa (12%),Staphylococcus aureus (8%) and Klebsiella pneumonia (3%).In our study A.baummannii showed approximate 100% resistance to all antibiotics,in a way that A.baumannii resistance to imipenem and meropenem and piperacillin/tazobactam each was 97.1%.The most resistance of Pseudomonas aeruginosa was 66.7% to each cefepime and ceftazidime and clavulanate/ticarcillin.Staphylococcus aureus showed 75% resistance to nafcillin,cloxacillin and resistance in case of vancomycin was not seen.Conclusion:In current study,A.baumannii had the most prevalence among VAP and this species is resistant to most of antibiotics.Using ceftazidime,cefepime and clavulanate/ticarcillin,in treatment of the patients suffering VAP is not reasonable.

关 键 词：ANTIBACTERIAL resistant VENTILATOR-ASSOCIATED PNEUMONIA INTENSIVE CARE unit 

分 类 号：R5[医药卫生—内科学]