Effect of perindopril on the myocardial energy consumption in patients with heart failure after myocardial infarction  

作　　者：Da-Peng Li Dang-Hui Sun Lin Wei Xi-Ying Yu Shi-Jin Na 

机构地区：[1]The First Hospital of Harbin City,Heilongjiang,150010 [2]The First Hospital Affiliated to Harbin Medical University,150011

出　　处：《Journal of Hainan Medical University》2017年第13期22-25,共4页海南医学院学报（英文版）

摘　　要：Objective:To explore the clinical efficacy of perinodopril in the treatment of heart failure in patients after myocardial infarction and effect on the myocardial energy consumption. Methods:A total of 87 patients with heart failure after myocardial infarction who were admitted in our hospital from August, 2014 to October, 2015 were included in the study and divided into the routine dose group (n=43, perinodopril 4 mg/d) and high dose group (n=44, perinodopril 8 mg/d) according to the long-term oral dose. All the patients were given perinodopril, continuously for 6 months. The changes of blood pressure and serum biochemical indicators before and after treatment in the two groups were compared. The changes of cardiac function indicators and myocardial energy consumption indicators before and after treatment in the two groups were compared. 6MWT 6 months and 1 year after treatment in the two groups was calculated.Results: The plasma BNP and H-FABP levels, LVEDD, LVESD, MEE, and cESS after treatment in the two groups were significantly reduced when compared with before treatment, and those in the high dose group were significantly lower than those in the low dose group. LVEF and FS after treatment in the two groups were significantly increased, and those in the high dose group were significantly greater than those in the routine dose group. The seurm potassium level after treatment in the high dose group was significantly elevated when compared with before treatment, but was not significantly different from that in the routine dose group. SBP, DBP, and Scr levels after treatment in the two groups were not significantly changed. 6MWT 6 months and 1 year after treatment in the high dose group was significantly greater than that in the routine dose group.Conclusions: Perinodopril in a high dose can significantly reduce the plasma BNP and H-FABP levels in patients with heart failure after myocardial infarction, inhibit the ventricular remodeling, promote the recovery of systolic function, reduce the myocardial energy con

关 键 词：MYOCARDIAL INFARCTION HEART failure Perinodopril CARDIAC function MYOCARDIAL energy CONSUMPTION 

分 类 号：R5[医药卫生—内科学]