Potential modifying effect of grip strength on the association between glycated hemoglobin(HbA1c)and all-cause mortality in older adults with type 2 diabetes:Evidence from UK Biobank  

作　　者：Jingyi Lu Yaxin Wang Yun Shen Yifei Mo Xiaojing Ma Gang Hu Jian Zhou 

机构地区：[1]Department of Endocrinology and Metabolism,Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai Clinical Center for Diabetes,Shanghai Key Clinical Center for Metabolic Disease,Shanghai Key Laboratory of Diabetes Mellitus,Shanghai 200233,China [2]Shanghai Diabetes Institute,Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China [3]Pennington Biomedical Research Center,Baton Rouge,LA 70808,USA

出　　处：《Chinese Medical Journal》2024年第12期1501-1503,共3页中华医学杂志（英文版）

基　　金：supported by the Program of Shanghai Academic/Technology Research Leader(No.22XD1402300);the Shanghai"Rising Stars of Medical Talent"Youth Development Program-Outstanding Youth Medical Talents(No.SHWSRS(2021)_099);the Shanghai Research Center for Endocrine and Metabolic Diseases(No.2022ZZ01002);the National Natural Science Foundation of China(No.31971485);the Shanghai Municipal Key Clinical Specialty.

摘　　要：To the Editor:Frailty status represents one of the core determinants for the individualization of glycated hemoglobin(HbA1c)targets in the elderly population.However,the most validated tools to quantify frailty,which are complex and involve multiple dimensions of assessment,are rarely used in the clinical practice of diabetes management.Therefore,a simple and practical metric for the evaluation of frailty is needed.Grip strength is an easily measurable,objective,and reproducible metric for assessing frailty status.[1]It is correlated with overall muscle strength and has been reported to be signicantly related to important health outcomes both in the general population[2,3]and in patients with diabetes.[4]Therefore,grip strength could be a useful marker for patient strati-cation in diabetes management.In this context,this study aimed to examine the associations between HbA1c and all-cause mortality across categories of grip strength,as a measure of frailty status,in older adults with type 2 diabetes in the UK Biobank.The researches had applied to access the UK Biobank database with the application approval number of 82812.

关 键 词：DIABETES MORTALITY strength 

分 类 号：R587.1[医药卫生—内分泌]